Objective：To observe the clinical effect of Yiqi Huoxue Jiedu prescription combined with acupuncture and moxibustion for patients with gastric disease concerning helicobacter pylori.Methods：Selected 274 cases of patients with gastric disease concerning helicobacter pylori，and divided them into the observation group and the control group randomly，137 cases in each group.The control group received basic medications(Lansoprazole enteric-coated tablets+Amoxicillin capsules+larithromycin Capsules)for treatment，while the observation group received acupuncture and moxibustion combined with Yiqi Huoxue Jiedu prescription.Statistically analyzed the clinical effect in both groups，changes of main symptoms and signs(stomachache，gastric distension，belching，poor appetite)before and after treatment，and changes of indexes of pepsinogen I(PGI)and pepsinogen II(PGII)and PGI/PGII before and after treatment.Results：The total effective rate was 98.54%in the observation group and 87.59%in the control group respectively，difference being significant(P＜0.05).Before treatment，comparing each score of stomachache，gastric distension，belching and poor appetite in both groups，there was no significant difference being found(P＞0.05).After treatment，each score of stomachache，gastric distension，belching and poor appetite in both groups was lower than that before treatment(P＜0.05)；each score of stomachache，gastric distension，belching and poor appetite in the observation group was significantly lower than that in the control group(P＜0.05).Before treatment，comparing the levels of PGI，PGII and PGI/PGII in both groups，there was no significant difference being found(P＞0.05).After treatment，the levels of PGI，PGII and PGI/PGII in both groups were higher than those before treatment(P＜0.05)；the levels of PGI，PGII and PGI/PGII in the observation group were significantly higher than those in the control group(P＜0.05).Conclusion：Yiqi Huoxue Jiedu prescription combined with acupuncture and moxibustion can improve the clinical symptoms and signs of patients with gastric disease concerning helicobacter pylori.It has relatively high clinical effect and can enhance the level of pepsinogen effectively.