Objective：To observe the clinical effect of Jianpi Shugan tang for functional dyspepsia with syndrome of disharmony between liver and stomach.Methods：Divided 70 cases of patients with functional dyspepsia with syndrome of disharmony between liver and stomach into the observation group and the control groupaccording to the random number tablein clinic，35 cases in each group.The control group received Domperidone tablets，while the observation group received self-made Jianpi Shugan tang.The treatment lasted for 4 weeks，and follow-ups for 6 months.Compared the clinical effect in both groups，and evaluated the symptom scores of patients in both groups before and after treatment.Results：The total effective rate was 94.29%in the observation group and 71.43%in the control group，difference being significant(P＜0.05).Scores of burning sensation in the upper abdomen，pain in the upper abdomen，early satiety and abdominal distension of both groups were lower than those before treatment，differences being significant(P＜0.01)；each score in the observation group was lower than that in the control group，differences being significant(P＜0.01).Conclusion：The prescription based on the method of dispersing liver，invigorating spleen and harmonizing stomach has more significant effect in both the short-term inhibitory symptoms and the long-term clinical effect when compared with western medicine，which is worthy of clinical application.