Objective：To observe the clinical effect of safflower injection for senile cerebral infarction.Methods：Divided 98 cases of patients with senile cerebral infarction into two groups randomly，46 cases in each group.The control group was given mannitol by intravenous drip and aspirin by oral administration，while the observation group was additionally given safflower injection by intravenous drip.The course of treatment lasted for 2 weeks.Observed and compared the clinical effect and neurological severity scores(NSS)in both groups，and detected the changes of hemodynamic index，plasma high sensitive C-reactive protein(hsCRP)，vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGF-β1).Results：The total effective rate was 87.86%in the observation group and 63.28%in the control group，difference being significant(P＜0.05).After treatment，scores of NSS in both groups were lower than those before treatment(P＜0.05)； the scores of NSS in the observation group were decreased more significantly than those in the control group(P＜0.05).After treatment，the levels of TGF-β1 and hsCRP in both groups were lower than those before treatment(P＜0.05)，and the level of VEGF was higher than that before treatment(P＜0.05)；the indexes above in the observation group were improved more than those in the control group(P＜0.05).After treatment，such indexes as plasma viscosity，hematocrit，erythrocyte aggregation index and fibrinogen of patients in both groups were significantly lower than those before treatment(P＜0.05)；each index above in the observation group was decreased more significantly than that in the control group(P＜0.05).Conclusion：Safflower injection has significant clinical effect in treating senile cerebral infarction，which can promote the recovery of neurological function of patients by decreasing the levels of hsCRP and TGF-β1 as well as increasing the level of VEGF.