Objective：To explore the medication features of Chinese medicine for chronic liver disease.Methods：Collected the prescriptions of chronic liver disease in ancient Chinese medicine literature of Chinese Medical Book(Zhong Hua Yi Dian)，established the database of prescriptions of chronic liver disease by Excel software，and conducted association rules analysis and cluster analysis on data by software of SPSS17.0 and IBM SPSS MODELER 18.0.Results：In terms of the frequency， that of reinforcing medicine was the highest， followed by blood-activating and stasis-resolving medicine，qi-regulating medicine and heat-clearing medicine.The result of association rules analysis showed that Rhizoma Sparganii and Rhizoma Curcumae，Radix Aucklandiae and Semen Arecae，and Radix et Rhizoma Glycyrrhizae and Rhizoma Chuanxiong were the most common compatible medications.The result of cluster analysis indicated that the correlation of Rhizoma Sparganii and Rhizoma Curcumae was the highest.Conclusion：Data analysis based on database of Chinese Medical Book(Zhong Hua Yi Dian)suggests that there are certain rules in Chinese medicine for chronic liver disease，which can provide a reference for clinical practice.