Objective：To observed the effect of Chinese medicine of Yiqi Huoxue Jiedu on cells autophagy of obstructive nephropathy.Methods：Randomly divided 48 male Wistar rats into the sham operation group，the model group，the valsartan group and the Chinese medicine group.Except the sham operation group，the other groups received unilateral ureteral obstruction to copy the animal model of obstructive nephropathy.The valsartan group and the Chinese medicine group were given 10 mg/(kg·d)of valsartan and 14 g/(kg·d)of Chinese medicine of Yiqi Huoxue Jiedu，and obstructed kidney of rats were taken after 10 d.Detected the expressions of serum and glucocorticoid induced kinase(SGK-1)，Autophagy associated gene 5(Atg5)，Beclin-1，microtubular-associated protein 1 light chain 3(LC3)，phosphorylated extracellular signal-regulated protein kinase(PERK1/2)and phosphorylated target of rapamycin(P-mTOR)by Western blot and immunohistochemistry.Results：Compared with those in the sham operation group，the expressions of Atg5，Beclin-1，LC3 II/I，SGK-1 and P-ERK1/2 in the model group were increased，while the expression of P-mToR was decreased，differences being significant(P＜0.01).Compared with those in the model group， the expressions of Atg5， Beclin-1， LC3 II/I， SGK-1 and P-ERK1/2 in the valsartan group and the Chinese medicine group were decreased， while the expression of P-mToR was increased，differences being significant(P＜0.05，P＜0.01).Conclusion：Chinese medicine of Yiqi Huoxue Jiedu can inhibit the activation of mineralocorticoid receptor(MR)by regulating the pathways of SGK-1，ERK1/2 and P-mTOR，so as to correct the abnormal of cells autophagy of obstructive nephropathy.