不同组方艾康片对细菌性和急性血清病肾炎的疗效研究
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R692.3

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“重大新药创制”科技重大专项项目(2014ZX09304306-006)


Study of Effect of Different Prescriptions of AiKang Tablets for Bacterial and Acute Serum Nephritis
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    摘要:

    目的:研究不同组方的艾康片在实验动物肾炎模型中的疗效,以获得更优药物组方。方法:SD大鼠随机分为假手术组、模型组、阿莫西林组、原方大剂量组、原方小剂量组、缺苦参大剂量组、缺苦参小剂量组,每组10只;膀胱内注射大肠杆菌(E.coli)制备细菌性肾炎模型,治疗后培养膀胱穿刺液;日本大耳白兔随机分为正常组、模型组、雷公藤片组、原方大剂量组、原方小剂量组、缺苦参大剂量组、缺苦参小剂量组,每组6只,注射牛血清白蛋白制备急性血清病肾炎模型,检测循环系统免疫复合物(Circulating immune complexes,CIC)、血肌酐(Creatinine,Cr) 和尿素氮(Blood urea nitrogen,BUN)。结果:在感染性细菌性肾炎模型中,与假手术组比较,模型组大鼠的膀胱穿刺液全部有细菌生长,提示造模成功;与模型组比较,阿莫西林组、原方小剂量组、缺苦参小剂量组大肠杆菌培养阳性的大鼠比例均明显下降(P<0.05)。在急性血清病肾炎模型中,与模型组比较,所有给药组的血清CIC含量均明显降低(P<0.05,P<0.01)。结论:艾康片2种组方的较小剂量对于E.coli感染性大鼠模型具有较为显著的疗效;在急性血清病肾炎模型中2种组方在降低CIC方面都显示出了有效性。综合2种疾病模型来看,原方药效更优。

    Abstract:

    Objective:To observe the effect of different prescriptions of AiKang tablets in the models of experimental animal nephritis.Methods:Divided SD rats randomly into the sham operation group,the model group,the amoxicillin group,the high-dose group of the original prescription,the small-dose group of the original prescription,the high-dose group lacking Kushen,and the small-dose group lacking Kushen,10 rats in each group.Made acute pyelonephritis models by means of intravesical injection of Escherichia coli(E.coli)and cultured bladder puncture drainage after treatment.Divided Japanese white rabbits randomly into the normal group,the model group,the tripterygium tablets group,the high-dose group of the original prescription,the small-dose group of the original prescription,the high-dose group lacking Kushen,and the small-dose group lacking Kushen,6 rabbits in each group.Prepared models of acute serum sickness nephritis by injecting with bovine serum albumin,and detected circulating immune complexes(CIC),creatinine(Cr)and blood urea nitrogen(BUN).Results:In the models of infectious pyelonephritis,compared with the sham operation group, all the bladder puncture drainage in the model group had bacterial growth,suggesting successful modeling;compared with the model group,the proportions of rats of positive culture of escherichia coli in the amoxicillin group,the small-dose group of the original prescription and the small-dose group lacking Kushen were all significantly decreased(P<0.05).In the models of acute serum sickness nephritis,compared with the model group,the content of serum CIC in all drug-administered groups was evidently reduced(P<0.05,P<0.01).Conclusion:The small-dose groups of Aikang tablets in the two different prescriptions have significant effects for infectious rat models with escherichia coli;in the models of acute serum sickness nephritis,the two different prescriptions show effectiveness in reducing CIC.In view of the two disease models,the original prescription is more effective.

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徐玉辉,高英杰,时宇静,孙静,毛鑫,王彦礼,曲天歌,雀晓兰.不同组方艾康片对细菌性和急性血清病肾炎的疗效研究[J].新中医,2018,50(12):4-7

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  • 在线发布日期: 2018-12-09
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