Objective：To observe the clinical effect of Xuefu Zhuyu tang com bined with auricular point sticking therapy for prim ary insom nia.Methods：Selected 96 cases of patients with prim ary insom nia and divided theminto the controlgroup and the observation group randomly， 48 cases in each group.The control group was given Xuefu Zhuyu tang， while the observation group additionally received auricular point sticking therapy.The two groups received treatment for three courses，ten days being one course.Compared scores of Pittsburgh sleep quality index(PSQI)including the scores of daytime dysfunction，quality of sleep，hypnotic medicine，the time of falling asleep，sleep disorder，sleep efficiency，sleep time and the total score；compared levels of relevant indexes in encephal of luctuograph technology including dopamine，γ -amino butyric acid，norepinephrine，glutam ate，acetylcholine and 5-hydroxytryptophan and compared contents of the interleukins-2(IL-2)and the interleukins-6(IL-6)in serumin the two groups before and after treatment.Results：Scores of the daytime dysfunction，quality of sleep，hypnotic medicine，the time of falling asleep，sleep disorder，sleep efficiency and sleep time of PSQIand the total scores in the two groups were all decreased when compared with those before treatment( P ＜0.05)，and the decrease of each score in the observation group was more obvious than that in the control group( P ＜0.05).After treatment，levels of dopamine and acetylcholine in the two groups were all decreased when compared with those before treatment( P ＜0.05)，and the decrease of the two levels in the observation group was more obvious than that in the control group( P ＜0.05).Levels ofγ-amino butyric acid，norepinephrine，glutam ate and 5-hydroxytryptophan in the two groups were all increased when compared with those before treatment( P ＜0.05)，and the increase of the four indexes in the observation group wasmore obvious than that in the controlgroup( P ＜0.05).After treatment，contents of the IL-2 and IL-6in serumin the two groups were all decreased when compared with those before treatment( P ＜0.05)，and the decrease of the contents in the observation group was more obvious than that in the controlgroup( P ＜0.05).Conclusion：The therapy of Xuefu Zhuyu tang com bined with auricular point sticking therapy for prim ary insom nia can reduce each score of PSQI，decrease the content of inflamm atory factors and improve the quality of sleep with accurate curative effect.