血府逐瘀汤联合耳穴贴压治疗原发性失眠临床观察
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R256.23; R246.6

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Prim ary insom nia;Xuefu Zhuyu tang;Auricular point sticking therapy;Pittsburgh sleep quality index(PSQI);Encephal of luctuograph technology;Inflamm atory factors


Clinical Observation on Xuefu Zhuyu Tang Com bined with Au ricu lar Poin t Sticking Therapy for Prim ary Insom nia
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    摘要:

    目的:观察血府逐瘀汤联合耳穴贴压治疗原发性失眠患者的临床疗效。方法:选取原发性失眠患者96例,随机分为对照组和观察组各48例。对照组予血府逐瘀汤治疗,观察组在对照组基础上联合耳穴贴压治疗。1疗程为10天,2组均治疗3疗程。比较2组治疗前后匹兹堡睡眠指数(PSQI)量表评分(包括日间功能障碍、睡眠质量、催眠药物、入睡时间、睡眠障碍、睡眠效率、睡眠时间和总评分)、治疗前后脑电超慢涨落图技术相关指标水平(包括多巴胺、γ-氨基丁酸、去甲肾上腺素、谷氨酸、乙酰胆碱、5-羟色胺水平)和血清白细胞介素-2(IL-2)、IL-6含量。结果:治疗后,2组PSQI日间功能障碍、睡眠质量、催眠药物、入睡时间、睡眠障碍、睡眠效率、睡眠时间和总评分均较治疗前降低( P <0.05),观察组各项评分均较对照组降低更明显( P <0.05)。治疗后,2组患者多巴胺、乙酰胆碱水平均较治疗前降低( P <0.05),观察组多巴胺、乙酰胆碱水平均较对照组降低更明显( P <0.05);2组γ-氨基丁酸、去甲肾上腺素、谷氨酸及5-羟色胺水平均较治疗前升高( P <0.05),观察组上述指标均较对照组升高更明显( P <0.05)。治疗后,2组血清IL-2及IL-6含量均较治疗前降低( P <0.05),观察组血清IL-2及IL-6含量均较对照组降低更明显( P <0.05)。结论:血府逐瘀汤联合耳穴贴压可降低原发性失眠患者PSQI各项得分,降低机体炎性因子含量,疗效肯定,可以提高患者睡眠质量。

    Abstract:

    Objective:To observe the clinical effect of Xuefu Zhuyu tang com bined with auricular point sticking therapy for prim ary insom nia.Methods:Selected 96 cases of patients with prim ary insom nia and divided theminto the controlgroup and the observation group randomly, 48 cases in each group.The control group was given Xuefu Zhuyu tang, while the observation group additionally received auricular point sticking therapy.The two groups received treatment for three courses,ten days being one course.Compared scores of Pittsburgh sleep quality index(PSQI)including the scores of daytime dysfunction,quality of sleep,hypnotic medicine,the time of falling asleep,sleep disorder,sleep efficiency,sleep time and the total score;compared levels of relevant indexes in encephal of luctuograph technology including dopamine,γ -amino butyric acid,norepinephrine,glutam ate,acetylcholine and 5-hydroxytryptophan and compared contents of the interleukins-2(IL-2)and the interleukins-6(IL-6)in serumin the two groups before and after treatment.Results:Scores of the daytime dysfunction,quality of sleep,hypnotic medicine,the time of falling asleep,sleep disorder,sleep efficiency and sleep time of PSQIand the total scores in the two groups were all decreased when compared with those before treatment( P <0.05),and the decrease of each score in the observation group was more obvious than that in the control group( P <0.05).After treatment,levels of dopamine and acetylcholine in the two groups were all decreased when compared with those before treatment( P <0.05),and the decrease of the two levels in the observation group was more obvious than that in the control group( P <0.05).Levels ofγ-amino butyric acid,norepinephrine,glutam ate and 5-hydroxytryptophan in the two groups were all increased when compared with those before treatment( P <0.05),and the increase of the four indexes in the observation group wasmore obvious than that in the controlgroup( P <0.05).After treatment,contents of the IL-2 and IL-6in serumin the two groups were all decreased when compared with those before treatment( P <0.05),and the decrease of the contents in the observation group was more obvious than that in the controlgroup( P <0.05).Conclusion:The therapy of Xuefu Zhuyu tang com bined with auricular point sticking therapy for prim ary insom nia can reduce each score of PSQI,decrease the content of inflamm atory factors and improve the quality of sleep with accurate curative effect.

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刘芳洁,张国梁,刘海英,唐蕾,王勇兴.血府逐瘀汤联合耳穴贴压治疗原发性失眠临床观察[J].新中医,2018,50(9):172-175

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  • 在线发布日期: 2018-09-04
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