Objective：To observe the clinical effect of modified Guizhi Daizhou tang and modified Taohong Siw u tang for vitiligo of stasis obstructing meridians and collaterals type.Methods：Divided 64 cases of patients with vitiligo of stasis obstructing meridians and collaterals type into the treatment group and the control group randomly，32 cases in each group.The two groups were treated with external app lication of Baibo tincture.The control group additionally received Licorzinegranules for treatment，while the treatment group additionally received modified Guizhi Daizhou tang and modified Taohong Siw u tang based on the treatment of the control group.The two groups were treated for six months.Compared the clinical effect in the two groups after 1， 3 and 6 months of treatment， scores of the skin lesion area and skin pigment before and after treatment， and recorded the adverse reactions in the two groups.Results：After 1， 3 and 6 months of treatment，the total effective rate was 37.50%，75.00%and 78.13%respectively in the treatment group，and 15.63%，46.88%and 53.13%respectively in the control group， differences between the two groups at the same time point being significant( P ＜0.05).After treatment， the skin lesion area in the two groups was decreased when compared with that before treatment( P ＜0.05).The skin lesion area in the treatment group was decreased more obviously than that in the control group( P ＜0.05).Scores of skin pigment in the two groups were increased when compared with those before treatment( P ＜0.05).The score of skin pigment in the treatment group was increased more obviously than that in the control group( P ＜0.05).The incidences of adverse reactions were both 9.38% in the two groups，there being no significance in the difference(P ＞ 0.05).Conclusion：The therapy of the oraladministration ofmodified GuizhiDaizhou tang and modified Taohong Siw u tang com bined with externalapplication of Baibo tincture has accurate therapeutic effect in treating vitiligo of stasis obstructing meridians and collaterals type，which can effectively reduce the skin lesion caused by vitiligo and accelerate the recovery ofmelanin in the skin.There was no obvious adverse reaction during the treatment.