Objective：To observe the clinical effect of Qingrun Yangmu oral liquid com bined with Jinzhen eye drops for asthenopia caused by video display terminal(VDT).Methods：Divided 70 cases of patients with asthenopia caused by VDT into the experiment group and the control group randomly，35 cases in each group.The control group was treated with Jinzhen eye drops，while the experiment group received Qingrun Yangmu oral liquid combined with Jinzhen eye drops for treatment.Compared the time of nearwork，symptomscores，visuognosis persistence and clinical effect in the two groups.Results：The totaleffective rate was 78.1%in the experiment group，being rem arkably higher than that of 57.6%in the controlgroup，the difference being significant( P ＜0.05).Before treatment，there was no significant difference being found in the comparisons of the time of nearwork，clinical symptomscores and visuognosis persistence between the two groups( P ＞0.05).After treatment，compared with those before treatment，the time of nearwork and visuognosis persistence in the two groups were obviously increased( P ＜0.01)；clinical symptomscores were obviously decreased( P ＜0.01).The time of nearwork and visuognosis persistence in the experiment group were obviously higher than those in the controlgroup( P ＜0.01)and the clinical symptomscore was lower than that in the control group( P ＜0.05).Conclusion：Both Qingrun Yangmu oral liquid and Jinzhen eye drops have effect in treating asthenopia caused by VDT.The therapeutic effect of the therapy of Qingrun Yangmu oral liquid com bined with Jinzhen eye drops is superior to that of simple administration of Jinzhen eye drops，which means that a comprehensive therapy has a better effect in treating asthenopia caused by VDT.