Objective：To observe the effect of Qingfei Jiedu tang on immune and coagulation state in children with lobar pneumonia，and provide research basis for its promotion and application in clinical practice.Methods：Divided 90 cases of children with lobar pneumonia into the treatment group and the control group，60 cases and 30 cases in each group respectively.The control group received routine basic treatment，while the treatment group received basic treatment com bined with Qingfei Jiedu tang.After treatment of two courses，observed the changes of indexes of immunity and coagulation before and after treatment in the two groups，and compared the safety of the two treatments.Results：Contents of CD3 + ， CD4 + ， CD4 + /CD8 + ， immunoglobulin A(IgA)and immunoglobulin G(IgG)in the two groups were significantly increased when compared with those before treatment.Blood p latelet count(BPC)，fibrinogen(Fib)and D-dimer(D-D)in the treatment group were significantly decreased when compared with those before treatment，while contents of throm bin time(TT)and activated partial throm boplastin time(APTT)were significantly increased.Content of CD8 + in the control group was significantly increased when compared with that before treatment，while the content of prothrom bin time(PT)was significantly decreased，differences being significant( P ＜0.05).After treatment，contents of CD3 + ，CD4 + ，CD4 + /CD8 + ，IgA，PT and TT were significantly increased when compared with those in the control group，while the contents of Fib and D-D were significantly decreased，differences being significant( P ＜0.05).The incidence of adverse reactions was 1.7%in the treatment group and was 23.3%in the control group，difference being significant( P ＜0.05).Conclusion：The therapy of Qingfei Jiedu tang can obviously improve immune and coagulation state of children，and has a positive significance in improving prognosis with high safety，which is worthy of promotion and application in clinicalpractice.