Objective：To observe theclinical effect of five-elementmusic com bined with modified Yiguanjian for patients with anxiety during perimenopause.Methods：Divided 75 cases of patients completed in the final study with mild-to-moderate anxiety during perimenopause into the control group 1，the control group 2 and the treatment group，25，20 and 30 cases in each group respectively.The control group 1 was treated with Yiguanjian；the control group 2 received five-element music for treatment；the treatment group was given five-element music com bined with Yiguanjian for treatment.The three groups were treated once a day，and the treatment lasted for two courses，one month being one course.Compared scores of Hamilton depression scale(HAMD)and Kupperm an scores before and after treatment.Detected levels of follicle-stimulating hormone(FSH)，luteinizing hormone(LH)and anti-mullerian hormone(AMH)in serum before and after treatment.Results：After treatment，scores of HAMD and Kupperm an in the control group 1 and the treatment group were decreased when compared with those before treatment( P ＜0.05).Compared scores of HAMD and Kupperm an in the control group 2 before and after treatment，there were no significance in the differences( P ＞ 0.05).Scores of HAMD and Kupperm anin the treatment group were decreased more obviously than those in the control group 1 and group 2( P ＜0.05).Scores of HAMD and Kupperm an in the controlgroup 1 were decreased more obviously than those in the controlgroup 2( P ＜0.05).After treatment，the FSH level in serumin the control group 1 was decreased when compared with that before treatment( P ＜0.05)，and was decreased when compared with that in the controlgroup 2( P ＜0.05).Compared levels of LHand AMH in the control group 1 before and after treatment，there were no significance in the differences( P ＞ 0.05).Compared levels of LH and AMH in the control group 1 with those in the control group 2，there were no significance in the differences(P＞ 0.05).After treatment，compared levels of FSH，LH and AMH in serumin the control group 2 before and after treatment，there were no significance in the differences( P ＞ 0.05).Levels of FSH and LH in serumin the treatment group were decreased when compared with those before treatment( P ＜0.05)，and were decreased when compared with those in the control group 1 and the control group 2( P ＜0.05).Compared the AMH level in the treatment group before and after treatment，there was no significance in the difference( P ＞ 0.05).Compared the AMH level in the treatment group with that in the controlgroup 1 and the controlgroup 2，there was no significance in the difference( P ＞ 0.05).After treatment，the total effective rate was 64.0%in the control group 1，20.0%in the control group 2 and 86.6%in the treatment group，differences being significant( P ＜0.05).Conclusion：Yiguanjian has a definite effecton the treatmentof anxiety in perimenopause.If com bined with five-elementmusic therapy，it can better improve anxiety symptoms and other physicaldiscom fort.