Objective：To observe the clinicaleffect of rituxim ab com bined with Zhenw u tang for lupus nephritis.Methods：Divided 51 cases of patients with lupus nephritis into the controlgroup and the observation group randomly，25 cases and 26 cases respectively in each group.The controlgroup was treated with simple rituxim ab injection while the treatment group was additionally given Zhenw u tang based on the treatment of the control group.Compared the changes in the relevant indicators before and aftermedication in the two groups，and compared and analyzed the therapeutic effects.Results：After treatment，levels of the serum creatinine(SCr)and urine protein quantitation in the two groups were decreased when compared with those before treatment( P ＜0.05)；levels of hemoglobin(Hb)and serum albumin were increased when compared with those before treatment( P ＜0.05).Levels of the SCr and urine protein quantitation in the observation group were lower than those in the control group( P ＜0.05)；levels of hemoglobin(Hb)and serum albumin were higher than those in the control group( P ＜0.05).After treatment，contents of C3 and C4 in the two groups were increased when compared with those before treatment( P ＜0.05).Contents of C3 and C4 in the observation group were higher than those in the control group( P ＜0.05).After treatment，levels of the erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)were decreased when compared with those before treatment( P ＜0.05).Levels of the ESR and CRP in the observation groupwere lower than those in the control group( P ＜0.05).After treatment，the positive rate and total effective rate of anti-dsDNA antibody in the observation group were lower than those in the controlgroup( P ＜0.05).Conclusion：The therapy of rituxim ab com bined with Zhenw u tang for lupus nephritis can improve the kidney function and relevant immunological indicators of patients and reduce the inflamm atory responses，whose therapeutic effect is better than that of simple administration of rituxim ab.