Objective：To observe the clinicaleffect of Ziyin Qingre prescription com bined with metformin tablets for type 2 diabetes mellitus with yin deficiency and excessive heat syndrome.Methods：Divided 123 cases of patients with type 2 diabetes mellitus with yin deficiency and excessive heat syndrome into the observation group and the controlgroup randomly，63 cases and 60 cases in each group respectively.The control group received oral administration of metformin tablets for treatment，while the observation groupwas additionally given Ziyin Qingre prescription.The two groups continuously received treatment for three months.After treatment，compared and analyzed the clinical effect in the two groups，and observed the improvement ofrelevant indexes including blood glucose，insulin and serum lipids.Results：The total curative rate was 95.24%in the observation group and was 83.33%in the control group，the difference being significant( P ＜0.05).After treatment，levels of fasting blood glucose(FBG)， postprandial 2 h blood glucose(P2hBG)， glycosylated hemoglobin(HbA1c)， fasting insulin(FINS)， insulin resistance index(IR)， total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)in the observation group were decreased when compared with those before treatment( P ＜0.05)；no significant difference was found in the comparisons of triglyceride(TG)and high density lipoprotein cholesterol(HDL-C)before and after treatment( P ＞0.05).Levels of FBG，P2hBG，HbA1c，FINS and IR in the control group were decreased when compared with those before treatment( P ＜0.05)；no significant difference was found in the comparisons of levels of TC，TG，HDL-C and LDL-C before and after treatment( P ＞ 0.05).After treatment，compared the levels of FBG，P2hBG，HbA1c，FINS，IR and TC in the two groups，differences were significant( P ＜0.05)；no significant difference was found in the comparisons of levels of TG，HDL-C and LDL-C in the two groups( P ＞0.05).Conclusion：In the therapy of Ziyin Qingre prescription com bined with metformin tablets for type 2 diabetes mellitus with yin deficiency and excessive heat syndrome，its improvement of blood glucose，serum lipidsandinsulin is better than that of the simple metformin tablets.