Objective：To observe the clinicaleffect of Zijinding combined with Sihuang Shuimi for subacute thyroiditis pain.Methods：Analyzed a total of 103 patients with subacute thyroiditis accompanied by thyroid pain retrospectively，including 52 cases in the observation group and 51 cases in the controlgroup.The controlgroup was given western medicine alone，while the observation group was additionally treated with Zijinding com bined with Sihuang Shuimi.Observed the clinical effect，improvements of the thyroid pain and the levels of thyroid function and erythrocyte sedimentation rate(ESR)in the two groups before and after treatment.Results：The total effective rate was 98.08%in the observation group and 90.20%in the control group，difference being significant( P ＜0.05).The complete improvement rate of pain was 96.15%in the observation group and 72.55% in the control group，difference being significant( P ＜0.01).The improvement time of thyroid pain in the observation group was shorter than that in the control group，difference being significant( P ＜0.01).After treatment，the thyroid function and ESR in the two groups were improved when compared with those before treatment，difference being significant( P ＜0.05).After treatment，the ESR level in the observation group was lower when compared with that in the controlgroup，difference being significant( P ＜0.05).Conclusion：The externalapplication of Zijinding com bined with Sihuang Shuimihas a good clinicaleffect in improving the subacute thyroiditis pain，which can be promoted clinically.