Objective：To observe the curative effect of YiqiHuoxue Tongm ai tang for unstable angina pectoris of coronary heart disease and its effect on levels of inflamm atory factors in serum.Methods：Selected 96 cases of patients with unstable angina pectoris of coronary heart disease and divided theminto two groups randomly，48 cases in each group.The two groups received routine treatment，and the observation group additionally received Yiqi Huoxue Tongm ai tang based on syndrome differentiation.The two groups received treatment continuously for four weeks.Monitored the changes of m ain physiological indexes，levels of C-reactive protein(CRP)，tumor necrosis factor-α (TNF-α )and interleukins-6(IL-6)in serum as well as the clinical effect in the two groups.Results：After treatment，the total effective rate was 70.8%in the control group and 85.4%in the observation group，the difference being significant( P ＜0.05).After treatment，the clinical symptoms in the two groups were obviously improved when compared with those before treatment；compared w eekly seizure times of angina pectoris and daily dosage of nitroglycerin before and after treatment，differences were significant( P ＜0.05).After treatment，compared w eekly seizure times of angina pectoris and daily dosage of nitroglycerin in the observation group with those in the control group，differences were significant( P ＜0.05).After treatment，compared levels of TNF-α ，CRP and IL-6 in serumin the two groups with those before treatment respectively，differences were significant( P ＜0.05).Compared levels of TNF-α ，CRP and IL-6 in serumin the observation group with those in the control group，differences were significant( P ＜0.05).Conclusion：The therapy of Yiqi Huoxue Tongm ai tang for unstable angina pectoris of coronary heart disease based on syndrome differentiation can obviously improve the clinical symptoms of patients and the levels of inflamm atory factors in serum.