Objective：To study the clinical effect of isosorbide mononitrate injection com bined with Xueshuantong injection for coronary heart disease with angina pectoris.Methods：Selected 106 cases of patients with coronary heart disease with angina pectoris into the control group and the treatment group according to random num ber table method，53 cases in each group.The control group was given routine treatment com bined with isosorbide mononitrate injection，while the treatment group additionally received Xueshuantong injection based on the treatment of the controlgroup.Observed and recorded scores of Chinese medicine syndromes，the blood lipid level in the two groups，symptoms scores of angina pectoris，and compared the clinicaleffect.Results：The totaleffective rate was 94.34%in the treatment group，which was obviously higher than that of 79.25%in the control group，the difference being significant( P ＜0.05).Before treatment，no significant difference was found in the comparisons of levels of serum lipids indexes including triglyceride(TG)， total cholesterol(TC)， high density lipoprotein cholesterol(HDL)and low density lipoprotein cholesterol(LDL)between the two groups( P ＞ 0.05)；no significant difference was found in the comparisons of scores of Chinese medicine syndromes including chest distress and chest pain，palpitation，nocturia and soreness and weakness of waist and knees between the two groups( P ＞ 0.05).After treatmentlevels of TC，TG and LDL in the two groups were significantly decreased when compared with those before treatment，and HDL levels were significantly increased when compared with those before treatment，and scores of Chinese medicine syndromes including chest distress and chest pain，palpitation，nocturia and soreness and weakness of waist and knees were decreased when compared with those before treatment，differences being significant( P ＜0.05).Compared with those in the control group respectively，levels of TC，TG and LDL in the control group were lower，HDL level was higher，and scores of Chinese medicine syndromes including chest distress and chest pain，palpitation，nocturia and soreness and weakness of waist and knees were lower， differences being significant( P ＜0.05).After treatment，scores of physical activity，attack frequency，degree of attack，treatment satisfaction，illness perceptions and total scores of symptoms in terms of symptoms scores of angina pectoris were remarkably higher than those in the control group，differences being significant( P ＜0.05).Conclusion：The curative effect of the therapy of isosorbide mononitrate injection com bined with Xueshuantong injection for coronary heart disease with angina pectoris in clinical practice is better than that of the simple isosorbide mononitrate injection.The therapy can effectively improve Chinese medicine syndromes，regulate blood fat and relieve angina pectoris，which is worthy of promotion and app lication in clinicalpractice.