温阳泄浊化湿中药结合刺络放血治疗急性痛风性关节炎临床研究
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R589.7

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东莞市社会科技发展项目 (201650715001682)


Clinical Study on Chinese Medicine of Warming Yang,Resolving Turbidity and Transforming Dampness Combined with Blood letting Puncture for Acute Gouty Arthritis
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    摘要:

    目的:观察温阳泄浊化湿中药结合刺络放血治疗急性痛风性关节炎(AGA)的临床疗效,并从免疫学方面探讨其作用机理。方法:将120例患者随机分为2组各60例。观察组采用温阳泄浊化湿中药结合刺络放血治疗;对照组采用双氯芬酸钠缓释片治疗。观察2组临床疗效、症状积分、疼痛视觉模拟评分法(VAS)评分及实验室指标血沉(ESR)、C-反应蛋白(CRP)、尿酸(UA)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α) 等。结果:愈显率观察组76.7%,对照组60.0%,2组比较,差异有统计学意义( P <0.05)。治疗后,2组症状积分、疼痛VAS评分分别比较,差异均有统计学意义( P <0.05)。治疗后,除ESR、CRP外,2组UA、IL-1β及TNF-α分别比较,差异均有统计学意义( P <0.05, P <0.01)。结论:温阳泄浊化湿中药结合刺络放血治疗AGA优于口服双氯芬酸钠缓释胶囊治疗,在免疫作用机制上有调整患者体液免疫的作用。

    Abstract:

    Objective: To observe the clinical effect of Chinese medicine of warming yang, resolving turbidity and transforming dampness combined with bloodletting puncture for acute gouty arthritis(AGA),and discuss its mechanismfromthe aspect of immunology.Methods:Divided 120 cases of patients into two groups,60 cases in each group.The observation group received Chinese medicine of warming yang,resolving turbidity and transforming dampness combined with bloodletting puncture for treatment,while the control group received diclofenac sodium sustained-release tablets.Observed the clinical effect, symptoms scores, pain scores of visual analogue scales(VAS)and laboratory indicators including erythrocyte sedimentation rate(ESR), C-reactive protein(CRP),uric acid(UA), interleukins-1β (IL-1β )and tumor necrosis factor- α(TNF-α )in the two groups.Results:The cured and remarkably effective rate was 76.7%in the observation group and 60.0%in the control group,the difference being significant(P < 0.05).After treatment,the comparisons of symptoms scores and pain scores of VAS between the two groups showed significance in differences(P < 0.05).After treatment,in addition to ESR and CRP,the comparisons of UA,IL-1β and TNF-α between the two groups showed significance in differences( P < 0.05,P < 0.01).Conclusion:The therapy of Chinese medicine of warming yang,resolving turbidity and transforming dampness combined with bloodletting puncture for AGA is better than that of diclofenac sodium sustained-release tablets.The therapy has an effect of adjusting humoral immunity of patients fromthe aspect of the immune mechanism.

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宁晓军,阮永队,洪潇挺,王蓉,马春玲,谢炎烽,林佳,余兰.温阳泄浊化湿中药结合刺络放血治疗急性痛风性关节炎临床研究[J].新中医,2018,50(7):185-188

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  • 在线发布日期: 2018-07-09
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