Objective：To observe the clinical effect of acupoint catgut-embedding therapy for functional dyspepsia of liver-depression and spleen-deficiency type， and discuss its functional mechanism.Methods： Divided 90 cases of FD patients of liver-depression and spleen-deficiency type into the acupoint catgut-embedding group，the Chinese medicine control group and the western medicine control group randomly，30 cases in each group.Each group received the corresponding therapeutic method for treatment.Observed the changes of symptomscores，the skin temperature of Zhongwan，Guanyuan and Ren-du meridians，and the content of somatostatin(SS)and Substance P(SP)in plasma of patients before and after treatment.Results：The total effective rate was 96.7%in the acupoint catgut-embedding group and 70.0%in the western medicine controlgroup，differences being significant(P ＜ 0.05).After treatment，symptomscores in the three groups were lower than those before treatment(P ＜ 0.05)，symptomscores in the acupoint catgut-embedding group were lower than those in the Chinese medicine control group and the western medicine control group(P ＜ 0.05)，and symptomscores in the Chinese medicine control group were lower than those in the western medicine control group( P ＜0.05).After treatment，the skin temperature of Zhongwan，Guanyuan and Ren-du meridians in the acupoint catgut-embedding group and the Chinese medicine control group was respectively higher than that before treatment(P ＜ 0.05)；comparing the skin temperature of each acupoint in the western medicine control group with that before treatment，there were no significant differences being found(P ＞ 0.05)；the skin temperature of each acupoint in the acupoint catgut-embedding group was higher than that in the Chinese medicine control group and the western medicine control group(P ＜ 0.05).After treatment，the content of SS in plasma of three groups was lower than that before treatment(P ＜ 0.05)，and the content of SP in plasma was higher than that before treatment(P ＜ 0.05)；the content of SS in plasma of the acupoint catgut-embedding group was respectively lower than that in the Chinese medicine control group and the western medicine control group(P ＜ 0.05)；the content of SP in plasma was respectively higher than that in the Chinese medicine control group and the western medicine control group(P ＜ 0.05)；the content of SS in plasma of the Chinese medicine control group was lower than that of the western medicine control group( P ＜0.05).Conclusion：Acupoint catgut-embedding therapy has significant clinical effect in treating FD of li ver-depression and spleen-deficiency type，and its functionalmechanismmay be relevant with regulating the content of SS and SP in plasma.