消囊丸联合常规西药治疗多囊卵巢综合征临床研究
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R711.75

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开封市科技攻关项目 (15030


Clinical Study on Xiaonang Pills Combined with Routine Western Medicine for Polycystic Ovary Syndrome
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    摘要:

    目的:观察消囊丸联合常规西药治疗多囊卵巢综合征(PCOS)的临床疗效。方法:选取198例PCOS患者,随机分成对照组和治疗组各99例。对照组服用黄体酮胶囊和炔雌醇环丙孕酮片,治疗组在对照组基础上加服消囊丸。对比分析2组临床疗效,检测治疗前后血清睾酮(T)、黄体生成素(LH)、雌二醇(E 2 )、卵泡刺激素(FSH)含量及LH/FSH比值,检测空腹胰岛素(FINS)、空腹血糖(FBG)、体质量指数(BMI)和腰/臀围比值(WHR)。结果:治疗组和对照组的总有效率分别为93.94%、73.74%,2组比较,差异有统计学意义( P <0.05)。治疗后,2组血清T、LH及LH/FSH水平均较治疗前下降( P <0.05),治疗组血清T、LH及LH/FSH水平均低于对照组( P <0.05);2组血清E 2 及FSH水平与治疗前比较及组间对比均无差异(P>0.05)。治疗后,2组子宫内膜厚度均较治疗前增大,卵巢体积均较治疗前缩小,窦卵泡数量均较治疗前减少,差异均有统计学意义( P <0.05);治疗组子宫内膜厚于对照组,卵巢体积小于对照组,窦卵泡数量少于对照组,差异均有统计学意义( P <0.05)。治疗后,治疗组FINS、BMI、FBG及WHR及对照组FINS、BMI均较治疗前降低,差异均有统计学意义( P <0.05);治疗组4项指标水平均低于对照组( P <0.05)。结论:消囊丸联合常规西药治疗可明显改善PCOS患者的血清性激素水平,增大子宫内膜厚度,缩小卵巢体积,减少窦卵泡数量,临床疗效显著。

    Abstract:

    Objective: To observe the clinical effect of Xiaonang pills combined with routine western medicine for polycystic ovary syndrome(PCOS).Methods:Selected 198 cases of patients with PCOS and randomly divided theminto the control group and the treatment group,99 cases in each group.The control group was treated with progesterone capsules and ethinylestradiol and cyproterone acetate tablets,while the treatment group was additionally treated with Xiaonang pills based on the treatment of the control group.Compared and analyzed curative effect in the two groups,and detected the contents of testosterone(T),luteinizing hormone(LH),estradiol2(E 2 ),follicle stimulating hormone(FSH)and LH/FSH ratio in serum.Detected levels of fasting insulin(FINS), fasting blood glucose(FBG), body mass index(BMI)and waist/hip ratio(WHR)before and after treatment.Results:The to taleffective rate of the treatment group and the controlgroup was 93.94%and 73.74%respectively,the difference being significant(P < 0.05).After treatment,levels of T,LH and LH/FSH in serumin the two groups were decreased when compared with those before treatment( P <0.05).Levels of T,LH and LH/FSH in serumin the treatment group were lower than those in the control group( P <0.05).There was no significant difference being found in the comparisons of levels of E 2 and FSH between the two groups before and after treatment(P>0.05).After treatment, the endometrial thickness in the two groups was increased when compared with that before treatment; the volume of ovary was reduced,the number of antral follicle was reduced.differences being significant( P <0.05).The endometrial thickness in the treatment group was larger than that in the control group,and the number of antral follicle was less;the volume of the ovary was smaller,differences being significant(P < 0.05).After treatment,levels of FINS,BMI,FPG and WHR in the treatment group and levels of FINS and BMIin the control group were decreased when compared with those before treatment,differences being significant(P < 0.05).Levels of the four indexes in the treatment group were lower than those in the control group( P <0.05).Conclusion:The therapy of Xiaonang pills combined with routine western medicine can obviously improve the levels of sex hormone in serumof patients with PCOS,increase the endometrial thickness,reduce the volume of ovary,reduce the number of antral follicle,and the clinicaleffect is remarkable.

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杜鹃,王利平,侯爱贞,赵阳,杨萌.消囊丸联合常规西药治疗多囊卵巢综合征临床研究[J].新中医,2018,50(7):135-138

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  • 在线发布日期: 2018-07-09
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