Objective：To observe the clinical effect of Kangfuxin liquid in the intervention for oral mucosa reaction after radiotherapy of nasopharyngeal carcinoma.M e th o d s：Divided 46 cases of patients with nasopharyngeal carcinoma who had oral mucosa reaction after radiotherapy into the control group and the observation group according to the random number table randomly，23 cases in each group.During the radiotherapy，the control group was rinsed with saline after three meals everyday，while the observation group was rinsed with Kangfuxin liquid.Observed the treatment for two weeks.Observed and compared the classification of oral muofcosa reaction in radiotherapy，the duration of oral mucosa reaction and the degree of pain[numerical rating scale(NRS)]in two groups.Results：After treatment，the degree of oral muofcosa reaction in the two groups were both improved when compared with those before treatment(P ＜ 0.05)，while the degree of oral muofcosa reaction in the observation group was lower than that in the control group，difference being significant(P＜0.05).The proportion of patients whose oral mucosa reaction disappeared after one week of treatment in the observation group was higher than that of the control group，difference being significant(P ＜ 0.01).After treatment，scores of NRS in two groups were both decreased when compared with those before treatment(P ＜ 0.05)，while the score of NRS in the observation group was lower than that of the control group(P＜0.05).Conclusion：To rinse oral cavity with Kangfuxin liquid can effectively reduce the clinical symptoms of the oral mucosa reaction after radiotherapy of nasopharyngeal carcinoma，reduce and relieve oral pain of patients，and shorten the course of disease.