Objective：To observe the clinical effect of Chaiju Guizhi tang for children with febrile diseases.M e th o d s：Divided 120 cases of children with febrile diseases into the observation group and the control group randomly，60 cases in each group.The observation group was given Chaiju Guizhi tang for treatment，while the control group was given symptomatic treatment of western medicine.The treatment lasted for four days.After treatment，detected levels of C-reactive protein(CRP)in the two groups，compared the antipyretic time，the recovery time of CRP and the disappearance time of concomitant symptoms.Compared the clinical effect and the incidence of adverse reactions in the two groups.Results：CRP values from the first day to the fourth day after treatment in the two group were decreased when compared with those before treatment(P＜0.05).No significant differences were found in the comparison of CRP value between the two groups on the first and the second day after treatment(P＞0.05).CRP values in the observation group were lower than that in the control group on the third and the fourth day after treatment(P＜0.05).No significant differences were found in the comparisons of the recovery time of CRP and the disappearance time of concomitant symptoms between the two groups(P＞0.05).The total effective rate was 98.3%in the observation group and 100%in the control group，there being no significance in the difference(P＞0.05).The incidence of adverse reactions was 11.6%in the observation group and 66.7%in the control group，the difference being significant(P ＜ 0.05).Conclusion：The curative effect of Chaiju Guizhi tang can be confirmed for children with febrile diseases，with lower incidence of adverse reactions and higher clinical value.