Objective：To discuss the clincial effect of Qingrun Yangmu prescription for xerophthalmia after keratorefractive surgery.M e th o d s：Divided 80 cases(160 eyes)of patients with xerophthalmia after keratorefractive surgery into the observation group and the control group randomly，40 cases(80 eyes)in each group.The control group was treated with hydroxyl glycoside eye drops，while the observation group was additionally given the oral administration of Qingrun Yangmu prescription of the granule formula.The treatment for both gorups lasted for 14 days.Compared the changes of scores of subjective symptoms of xerophthalmia before and after drug withdrawal for 15 days，scores of corneal fluorescite staining(CFS)and values of schirmer's I test(SIt)and tear break-up time(BUT)，and evaluated the clinical effect of both groups.Results：After treatment，compared the scores of subjective symptoms of xerophthalmia，scores of CFS and values of SIt and BUT in both groups with those before treatment，there were significant differences being found(P ＜ 0.05)； compared each index in the observation group with that in the control group，there were significant differences being found(P＜0.05).On the 15thday after drug withdrawal，the scores of subjective symptoms of xerophthalmia and CFS scores in both groups were comparatively higher than those after treatment(P ＜ 0.05)，and the values of SIt and BUT were both lower than those after treatment(P ＜ 0.05)，when compared with those before treatment，there were significant differences being found(P ＜0.05)；comparing each index in the observation group with that in the control group，there was significant difference being found(P＜0.05).The total effective rate was 85.0%in the observation group and 77.5%in the control group，no difference being significant(P＞ 0.05).The markedly effective rate was 52.5%in the observation group and 25.0%in the control group，difference being significant(P＜0.05).Conclusion：Qingrun Yangmu prescription of the Chinese herbal granule formula has a better clinical effect than the simple application of artificial tears in treating xerophthalmia after keratorefractive surgery，which helps to release the eye discomforts and improve the vision quality of patients.