Objective：To observe the clinical effect of oral administration of Yangyin Qingfei tang combined with ultrasonic atomization with stock solution of herbal decoction for xerophthalmia with lung-yin deficiency syndrome.M e th o d s：Divided 95 cases of patients diagnosed with xerophthalmia into two groups，51 cases in the treatment group and 44 cases in the control group.The treatment group received the oral administration of ultrasonic atomization，while the control group received sodium hyaluronate eye drops for treatment.Observed the clinical effect of Chinese medicine syndrome，scores of clinical symptoms，break-up time(BUT)，Schirmer Itest(SIt)and fluorescent(FL).Results：Comparing the clinical effect of Chinese medicine syndrome in both groups，the total effective rate was 96.08%in the treatment group and 75.00%in the control group，difference being significant(P ＜ 0.05).After treatment，comparing each index of BUT，SIt and FL and scores of s y m p to m s in the treatment group with those in the control group respectively，there were significant differences being found(P ＜ 0.01)，and the treatment group was better than the control group.Conclusion：The oral administration of Yangyin Qingfeitang combined with ultrasonic atomization with stock solution of herbal decoction can effectively treat xerophthalmia with lung-yin deficiency syndrome，and its clinical effect is better than that of the simple application of Hialid eye drops.