Objective：To observe the clinical effect of Lidan tang combined with ursodeoxycholic acid tablets for intrahepatic cholestasis during pregnancy.M e th o d s：Selected 80 cases of patients with intrahepatic cholestasis during pregnancy，and divided them into the control group and the treatment group randomly，40 cases in each group.The control group was given ursodeoxycholic acid tablets for treatment，while the treatment group was given Lidan tang combined with ursodeoxycholic acid tablets for treatment.Compared the clinical effect，pruritus score，biochemical index and pregnancy outcome int wogroups.Results：The total effective rate was 92.5%in the treatment group and was 75.0%in the control group，difference being significant(P ＜ 0.05).After treatment，pruritus scores in two groups were both decreased when compared with those be fore treatment(P ＜ 0.05)，while the pruritus scores in the treatment group were lower than that in the control group(P ＜ 0.05).After treatment，levels of alanine aminotransferase(ALT)，aspartate aminotransferase(AST)，total bile a c id(T B A)， direct bilirubin(DBil)， indirect bilirubin(IBil)and total bilirubin(TBil)in two groups were all decreased when compared with those before treatment(P ＜ 0.05)，while the decrease of the previous 6 indexes in the treatment group was more obvious than that in the control group(P＜0.05).There was no significant difference being found in the comparisons of th e incidence of polluted amniotic fluid，perinatal mortality and neonatal asphyxia in two groups(P＞0.05).Cesarean section rate and premature birth rate in the treatment group were lower than those in the control group，differences being significant(P＜0.05).Conclusion：The therapy of modified Lidan tang based on ursodeoxycholic acid tablets for intrahepatic cholestasis during pregnancy can improve clinical effect and pruritus symptoms and biochemical indexes of patients，and reduce adverse pregnancy outcomes.