Objective：To observe the clinical effect of Yishen Shugan tang combined with moxibustion at Guanyuan point for follicular immature infertility.M e th o d s：Divided 120 cases of patients with follicular immature infertility of kidney-yin deficiency and stagnation of liver-qi type into the control group and the combination group randomly，60 cases in each group.The control group was given Yishen Shugan tang for treatment at the fourth day after menstruation，while the combination group was given Yishen Shugan tang combined with moxibustion at Guanyuan point for treatment.The treatment of both groups lasted for three menstrual cycles.After that，compared the endometrial thickness，cervical Insler score，number of mature follicles，ovulation rate and pregnancy rate of patients after treatment and sex hormone[follicle stimulating hormone(FSH)，estradiol，progesterone and luteinizing hormone(LH)]levels before and after treatment in the two groups.Results：The ovulation rate and pregnancy rate in the combination group were both higher than those in the control group(P＜0.05).The number of mature follicles in the combination group was more than that in the control group，and Insler score and endometrial thickness in the combination group were both better than those in the control group，differences being significant(P＜0.05).FSH in serum，estradiol，progesterone and LH level in the combination group were all lower than those before treatment，differences being significant(P＜0.01).The level of each index in the combination group was lower than that in the control group(P＜0.01，P＜0.05).Conclusion：The application of Yishen Shugan tang combined with moxibustion in treating follicular immature infertility of kidney-yin deficiency and stagnation of liver-qi type can effectively regulate the sex hormone levels of patients，increase the follicle maturation rate and pregnancy rate，and has a significant clinical effect.