Objective：To discuss the effect of tripterygium wilfordii polyglycosidium(TWP)combined with total glucosides of paeony(TGP)on rheumatoid arthritis(RA)，and comprehensively evaluated its clinical effect.M e th o d s：Selected 78 cases of RA patients admitted and treated in our hospital，and divided them into two groups according to the order of hospitalization，39 cases in each group.The control group was given the simple TGP for treatment，while the observation group was given the protocol of TWP combined with TGP for treatment.The treatment for both groups lasted for 3 months continuously.Observed the changes of relevant immune indexes and the improvement of symptoms in both groups before and after treatment，and comprehensively evaluated the clinical effect and adverse reactions.Results：No cases withdrew halfway or dropped out in this research.After treatment，CD3+and CD8+in both groups were significantly increased，CD4+and CD4+/CD8+were significantly decreased，differences being significant(P ＜ 0.05)；when comparing in-between the two groups after treatment，there was significant difference being found(P ＜ 0.05).After treatment，the indexes of morning stiffness，joint swelling and tenderness in both groups were all significantly decreased(P ＜ 0.05)；when comparing in-between the two groups after treatment，each index above in the observation group was reduced more evidently(P ＜ 0.05).The total effective rate in the observation group was higher than that in the control group，difference being significant(P＜0.05).During the treatment， the medication administration in both groups was quite stable， and no severe adverse reactions occurred.C o n c lu s io n：TWP combined with TGP can effectively improve the immune function，symptoms and signs of RA patients with good clinical effect and safety.