阳和汤联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎临床研究
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R684.3

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Clinical Research of Yanghe Tang Combined with Intra-articular Injection of Sodium Hyaluronate for Knee Osteoarthritis
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    摘要:

    目的:研究阳和汤联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎(KOA)的临床疗效。方法:将103例KOA患者随机分成观察组52例和对照组51例。对照组给予玻璃酸钠关节腔内注射治疗,观察组在对照组基础上加服阳和汤治疗,2组患者均连续治疗5周。比较2组的临床疗效,评定2组的症状积分,测定治疗前后血清内肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、IL-1β、基质金属蛋白酶13(MMP-13)、MMP-12和MMP-9的含量。结果:治疗后,总有效率观察组为94.12%,对照组为80.77%,2组比较,差异有统计学意义(P<0.05);2组症状积分均较治疗前下降(P<0.05),观察组症状评分较对照组下降更为明显(P<0.05);对照组患者血清hs-CRP、IL-1β、MMP-13、MMP-12和M M P-9均较治疗前含量下降(P<0.05),观察组患者血清TNF-α、hs-CRP、IL-6、IL-1β、MMP-13、MMP-12和M M P-9较治疗前和对照组均有明显下降,差异均有统计学意义(P<0.05)。结论:阳和汤联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎疗效显著,可有效改善临床症状,降低血清内相关炎症因子和细胞因子水平。

    Abstract:

    Objective:To observe the clinical effect of Yanghe tang combined with intra-articular injection of sodium hyaluronate for knee osteoarthritis(KOA).Methods:Divided 103 cases of patients with knee osteoarthritis into two groups randomly,52 cases in the observation group and 51 cases in the control group.The control group received intra-articular injection of sodium hyaluronate for treatment,while the observation group additionally received Yanghe tang.The treatment of the two groups continuously lasted for five weeks.Compared the clinical effect in the two groups.Evaluated the symptom scores and detected contents of tumor necrosis factor(TNF- α ),high sensitive C-reactive protein(hs-CRP),interleukin-6(IL-6), IL-1β , matrix metalloproteinase-13(MMP-13), MMP-12 and MMP-9 in serum before and after treatment.Results:After treatment,the total effective rate was 94.12%in the observation group and was 80.77%in the control group,the difference being significant(P<0.05).The symptom scores in the two groups were decreased when compared with those before treatment(P < 0.05),and the decrease of symptom scores in the observation group was more obvious than that in the control group(P<0.05).Contents of hs-CRP,IL-1β,MMP-13,MMP-12 and MMP-9 in serum in the control group were decreased when compared with those before treatment(P < 0.05).Levels of TNF-α ,hs-CRP,IL-6,IL-1β ,MMP-13,MMP-12 and MMP-9 in serum in the observation group were obviously decreased when compared with those in the control group and those before treatment,the differences being significant(P < 0.05).Conclusion:The therapy of Yanghe tang combined with intra-articular injection of sodium hyaluronate has significant curative effect in treating knee osteoarthritis,which can effectively improve clinical symptoms and reduce levels of inflammatory factors and cytokine in serum of patients.

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陈星,高文飞.阳和汤联合玻璃酸钠关节腔内注射治疗膝关节骨性关节炎临床研究[J].新中医,2018,50(6):112-114

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  • 在线发布日期: 2018-06-05
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