Objective：To observe the clinical effect of Yanghe tang combined with intra-articular injection of sodium hyaluronate for knee osteoarthritis(KOA).Methods：Divided 103 cases of patients with knee osteoarthritis into two groups randomly，52 cases in the observation group and 51 cases in the control group.The control group received intra-articular injection of sodium hyaluronate for treatment，while the observation group additionally received Yanghe tang.The treatment of the two groups continuously lasted for five weeks.Compared the clinical effect in the two groups.Evaluated the symptom scores and detected contents of tumor necrosis factor(TNF- α )，high sensitive C-reactive protein(hs-CRP)，interleukin-6(IL-6)， IL-1β ， matrix metalloproteinase-13(MMP-13)， MMP-12 and MMP-9 in serum before and after treatment.Results：After treatment，the total effective rate was 94.12%in the observation group and was 80.77%in the control group，the difference being significant(P＜0.05).The symptom scores in the two groups were decreased when compared with those before treatment(P ＜ 0.05)，and the decrease of symptom scores in the observation group was more obvious than that in the control group(P＜0.05).Contents of hs-CRP，IL-1β，MMP-13，MMP-12 and MMP-9 in serum in the control group were decreased when compared with those before treatment(P ＜ 0.05).Levels of TNF-α ，hs-CRP，IL-6，IL-1β ，MMP-13，MMP-12 and MMP-9 in serum in the observation group were obviously decreased when compared with those in the control group and those before treatment，the differences being significant(P ＜ 0.05).Conclusion：The therapy of Yanghe tang combined with intra-articular injection of sodium hyaluronate has significant curative effect in treating knee osteoarthritis，which can effectively improve clinical symptoms and reduce levels of inflammatory factors and cytokine in serum of patients.