Objective：To observe the clinical effect of α -lipoic acid combined with salvia injection for diabetic peripheral neuropathy(DPN)，and its effect on the levels of malondialdehyde(MDA)and superoxide dismutase(SOD)in serum.M e th o d s：Divided 110 cases of DPN patients into the treatment group and the control group randomly，55 cases in each group.Both groups received the routine treatment for diabetes，while the control group additionally received mecobalamin tablets，and the treatment group was additionally given α-lipoic acid combined with salvia injection for treatment.The treatment for both groups lasted for 4 weeks.Compared the nerve conduction velocity and clinical effect of both groups，and observed the changes of levels of MDA and SOD in serum of patients before and after treatment.Results：The total effect rate was 90.91%in the treatment group and 74.55%in the control group，difference being significant(P ＜ 0.05).After treatment，the motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)in the median nerve and common peroneal nerve in both groups were faster than those before treatment，differences being significant(P ＜ 0.05)；MNCV and SNCV in the treatment were both faster than those in the control group，differences being significant(P＜0.05).After treatment，MAD levels in both groups were lower than those before treatment(P ＜ 0.05)，and SOD levels were higher than those before treatment(P ＜ 0.05)；MAD levels in the treatment group were lower than those in the control group(P ＜ 0.05)，and SOD levels were higher than those in the control group(P＜0.05).Conclusion：α-lipoic acid combined with salvia injection has a significant effect in treating DPN.