半夏泻心汤联合三联疗法治疗慢性萎缩性胃炎临床观察
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R573.3+2

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Clinical Observation of Banxia Xiexin Tang Combined with Triple Therapy for Chronic Atrophic Gastritis
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    摘要:

    目的:观察半夏泻心汤联合三联疗法治疗慢性萎缩性胃炎的临床疗效。方法:选取9 0例寒热互结型慢性萎缩性胃炎患者,随机分为对照组和观察组各4 5例,对照组给予阿莫西林胶囊、雷贝拉唑钠肠溶胶囊、枸橼酸铋钾胶囊进行治疗,观察组在对照组基础上辨证使用半夏泻心汤加减进行治疗。2组均连续治疗8周。观察2组患者临床症状与血清中超氧化物歧化酶(S O D)、丙二醛(M D A)水平的变化,统计2组的幽门螺杆菌(H p)转阴率及临床疗效。结果:观察组总有效率9 3.3%,对照组总有效率7 3.3%,2组比较,差异有统计学意义(P<0.05)。2组胃脘胀痛、痞满烦闷、食少纳呆和嘈杂反酸积分均较治疗前降低,差异均有统计学意义(P<0.05);观察组4项积分均低于对照组,差异均有统计学意义(P<0.05)。观察组H p转阴率为9 1.1%,对照组H p转阴率为7 1.1%,2组H p转阴率比较,差异有统计学意义(P<0.05)。2组S O D水平均较治疗前上升,M D A水平均较治疗前下降,差异均有统计学意义(P<0.05);观察组S O D水平高于对照组,M D A水平低于对照组,差异均有统计学意义(P<0.05)。结论:半夏泻心汤联合三联疗法治疗寒热互结型慢性萎缩性胃炎可显著改善患者的临床症状,提高H p转阴率及临床疗效。

    Abstract:

    Objective:To observe the clinical effect of Banxia Xiexin tang combined with triple therapy for chronic atrophic gastritis.M e th o d s:Selected 90 cases of patients with chronic atrophic gastritis of intertwined cold and heat type,and divided them into the control group and the observation group randomly,45 cases in each group.The control group was given amoxicillin capsules,rabeprazole sodium enteric-coated capsules and colloidal bismuth subcitrate capsules for treatment,while the observation group was additionally given Banxia Xiexin tang based on the syndrome differentiation for treatment.The treatment for both groups lasted for 8 weeks.Observed the changes of clinical symptoms and levels of superoxide dismutase(SOD)and malondialdehyde(MDA)in serum of both groups,and statistically analyzed the negative rates of helicobacter pylori(Hp)in both groups and the clinical effect.Results:The total effective rate was 93.3%in the observation group and 73.3%in the control group,difference being significant(P<0.05).Each score of distention and pain in the epigastrium,distention and irritancy,low food intake and loss of apetite as well as epigastric upset and acid regurgitation in both groups were lower than those before treatment,differences being significant(P < 0.05);the four scores in the observation group were lower than those in the control group,differences being significant(P<0.05).The clearance rate of Hp was 91.1%in the observation group and 71.1%in the control group,difference being significant(P<0.05).The levels of SOD in both groups were higher than those before treatment,and the levels of MDA were lower than those before treatment,differences being significant(P < 0.05);the level of SOD in the observation group was higher than that in the control group,and the level of MDA was lo w e r than that in the control group,differences being significant(P < 0.05).Conclusion:Banxia Xiexin tang combined with trip letherapy for chronic atrophic gastritis can significantly improve the clinical symptoms of patients,and promote the negative rate of Hp as well as the clinical effect.

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陈武忠.半夏泻心汤联合三联疗法治疗慢性萎缩性胃炎临床观察[J].新中医,2018,50(6):93-95

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  • 在线发布日期: 2018-06-05
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