Objective： To observe the clinical effect of Gegen Qinlian Weiwan combined with naloxone based on the routine treatment for acute alcoholism.Methods：Selected 84 cases of patients with acute alcoholism，and divided them into the observation group and the control group randomly，42 cases in each group.Both groups received the routine treatment，and the control group was additionally given naloxone hydrochloride for injection，while the observation group was additionally given Gegen Qinlian Weiwan combined with naloxone hydrochloride for injection.Observed and compared the clinical effect，Glasgow coma scale(GCS)scores，the time for the consciousness returning to normal，the time for limb motor function returning to normal and the symptom disappearance time in both groups.Results：After treatment，the total effective rate was 100%in the observation group and 88.1%in the control group，difference being significant(P＜0.05).GSC scores in both groups were higher than those before treatment，difference being significant(P ＜ 0.05)；GCS scores in the observation group were higher than those in the control group，differences being significant(P＜0.05).The time for the consciousness returning to normal，the time for limb motor function returning to normal and the symptom disappearance time in the observation group were respectively shorter than those in the control group，differences being significant(P＜ 0.05).C o n c lu s io n：The additional application of Gegen Qinlian Weiwan combined with naloxone based on the routine treatment can make the consciousness and limb function of patients gradually recover in a comparatively short time，thus to reach the goal of quickly sobering up and promoting the clinical effect.