Objective：To observe the clinical effect of Liuyu tang in adjuvant treatment of hyperglycemia and dyslipidemia induced by atypical antipsychotic.M e th o d s：Selected 90 cases of patients with hyperglycemia and dyslipidemia induced by atypical antipsychotic，and divided them into the observation group and the control group randomly，45 cases in each group.Both groups received metformin hydrochloride sustained-release tablets and simvastatin tablets，while the observation group additionally received Liuyu tang for adjuvant treatment.Observed the changes of scores of positive and negative syndrome scale(PANSS)and relevant indexes of blood glucose and blood lipid in both groups before and after treatment，calculated pancreatic β -cell function index(Homa- β )and insulin resistance index(Homa-IR)，and analyzed the clinical effect.R e s u lts：After treatment，the scores of positive symptoms，negative symptoms，general pathological symptoms and the total scores in both groups were all decreased(P ＜0.05)，and the scores of positive symptoms，negative symptoms，general pathological symptoms and the total scores in the observation group were all lower than those in the control group(P＜0.05).After treatment， the levels of fasting blood glucose(FBG)， 2 h postprandial blood glucose(P2hBG)， glycosylated hemoglobin(HbA1c)in both groups and Homa-IR in observation group were all lower than those before treatment(P ＜0.05)，while the levels of Homa-β in observation group increased(P ＜0.05)，and the levels of FBG，P2hBG，HbA1c and Homa-IR in the observation group were respectively lower than those in the control group(P ＜0.05)，while the level of Homa-β was higher than that in the control group(P ＜ 0.05).After treatment，the levels of total cholesterol(TC)，triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in both groups were all lower than those before treatment(P＜0.05)，while the levels of high density lipoprotein cholesterol(HDL-C)and lipoprotein A(LPA)were all higher than those before treatment(P ＜0.05)，and the levels of TC，TG and LDL-C in the observation group were respectively lower than those in the control group(P＜0.05)，while the levels of HDL-C and LPA were higher than those in the control group(P＜0.05).The total effective rates of the clinical effect of hyperglycemia and dyslipidemia were 92.68%and 90.24%in the observation group and 76.19%and 71.43%in the control group respectively，differences being significant(P＜0.05).No severe adverse reactions occurred in both groups.Conclusion：Liuyu tang in adjuvant treatment of hyperglycemia and dyslipidemia induced by atypical antipsychotic can promote the clinical effect with medication safety.