Objective：To observe the clinical effect of Huatan Quyu tang for cerebral infarction of acute stage and its effect on the coagulation-fibrinolysis system and neurological function recovery of patients.Methods：Selected 98 cases of patients with cerebral infarction of acute stage，and divided them into the observation group and the control group according to the random number table method，49 cases in each group.The control group was treated with routine western medicine，while the observation group was additionally given Huatan Quyu tang based on the treatment of the control group.After two weeks of treatment，observed the improvement of symptoms，signs and neurological function，analyzed the therapeutic effect，and recorded the changes of each index of coagulation-fibrinolysis system.Results：The total effective rate was 91.84%in the observation group and was 77.55%in the control group，the difference being significant(P＜0.05).After treatment，scores of the symptoms，signs and NIH stroke scale(NIHSS)were decreased when compared with those before treatment(P＜0.05).Scores of the symptoms，signs and NIHSS in the observation group were lower than those in the control group(P ＜ 0.05).After treatment，levels of the plasma D-dimer(D-D)and the plasminogen activator inhibitor-1(PAI-1)in the two groups were decreased(P ＜ 0.05)，while levels of the plasma tissue plasminogen activator(tPA)in the two groups were increased(P＜0.05).The increase or the decrease of three relevant indexes of coagulation-fibrinolysis system in the observation group was greater than that of control group(P＜0.05).Conclusion：The therapy of Huatan Quyu tang combined with routine western medicine for patients with cerebral infarction of acute stage can effectively improve the symptoms and signs，promote fibrinolys is and neurological function recovery，and reduce thrombosis.