Objective： To observe the clinical effect of integrated Chinese and western medicine therapy for chronic congestive heart failure.Methods：Divided 124 cases of patients with chronic congestive heart failure with syndrome of both yin-qi deficiency and blood stasis into the treatment group and the control group randomly，62 cases in each group.The control group was given the routine treatment，while the treatment additionally received Shengmai Huayu Prescription for treatment.The treatment for both groups lasted for 6 weeks.Compared the indexes of cardiac function[[left ventricular ejection fraction(LVEF)， peak early diastolic velocity/peak late diastolic velocity(E/A)]，scores of syndrome and symptom in Chinese medicine，serum endothelin(ET)and brain natriuretic peptide(BNP)of both groups before and after treatment as well as the clinical effect after treatment.Results：After treatment，the total effective rate was 95.16%in the treatment group，being higher than 80.65%in the control group，difference being significant(P＜0.05).LVEF and E/A in both groups were higher than those before treatment(P ＜ 0.01)；LVEF and E/A in the treatment group were higher than those in the control group(P ＜ 0.01).Scores of palpitation，shorthness of breath，hypodynamia，dry mouth，spontaneous perspiration and night sweat in both groups were respectively lower than those before treatment(P ＜ 0.01)；each score above in the treatment group was all lower than that in the control group(P＜0.01).The levels of seruMetand BNF in both groups were all lower than those before treatment(P ＜ 0.01)；the levels of seruMetand BNF in the treatment group were all lower than those in the control group(P＜0.01).Conclusion：Integrated Chinese and western medicine therapy has a significant effect in treating chronic congestive heart failure，which is better than the simple treatment with western medicine，and one of the functional mechanism may be the down-regulation of levels of ET and BNP.