咳嗽变异性哮喘中医证治用药规律数据挖掘分析
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R256.12

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国家中医临床研究基地业务建设科研专项课题(JDZX2015200);广东省科学技术厅一广东省中医药科学院联合科研项目 (2014A20221112)


Data Mining Analysis of Drug Using Regularity in Chinese Medicine Syndrome for Cough Variant Asthma
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    摘要:

    目的:通过文献挖掘分析咳嗽变异性哮喘的用药规律和特点。方法:系统检索中医药治疗咳嗽变异性哮喘的经验类、病例报告类、临床研究类等文献,对处方、用药进行频数分析,采用改进的互信息法对临证特点及用药规律进行分析。结果:对筛选出的112味中药进行分析,确定药物的使用频次,治疗咳嗽变异性哮喘以解表药的使用频率最高,其次为止咳平喘药,使用频次较高的药物是麻黄、陈皮、柴胡、半夏、蝉蜕。通过药物之间的关联规则分析,演化得出麻黄-半夏-蝉蜕等核心组合。结论:临床治疗咳嗽变异性哮喘,在遵循中医辨证论治的前提下,应重视疏风宣肺药和化痰止咳平喘药的使用;若患者因伏风深潜于肺络且顽固难除,应适当应用虫类熄风药;不论新病久病,都应适当应用调中益气、活血之药。

    Abstract:

    Objective:To analyze the drug using regularity and features in treating cough variant asthma through literature mining.Methods:Systematically retrieved the literature about Chinese medicine in treating cough variant asthma in experience,case report and clinical research,analyzed the prescriptions and application of drugs in terms of frequency analysis,and dissected the clinical experience features and drug using regularity by adopting improved mutual information method.Results:The selected 112 Chinese herbs were analyzed so as to determine the frequency of use of the drugs.The highest frequency of drug use in treating cough variant asthma was diaphoretics drug,followed by cough-relieving and anti-asthmatic drugs.The other drugs with higher frequency of use were ephedra,dried tangerine peel,bupleurum,pinellia ternate and cicada slough.Through the analysis of association rules among drugs,a core combination of ephedra,pinellia ternate and cicada slough evolved.Conclusion:In the clinical treatment of cough variant asthma,under the premise of following Chinese medicine syndrome differentiation and treatment,attention should be paid to the application of wind-sparing and lung-promoting medicine and phlegm-dissipating and cough-and asthma-relieving medicine.If patients are sick due to the volatile wind which is deeply buried in the lung collaterals so that the disease is stubbornly difficult to remove,they should be appropriately given insecticidal anti wind medicine.Regardless of the new diseases or the diseases lasting for a long period of time,they should all be appropriately given drugs of regulating the center and benefiting qi or activating blood.

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宋苹,张溪,张忠德.咳嗽变异性哮喘中医证治用药规律数据挖掘分析[J].新中医,2018,50(6):51-54

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  • 在线发布日期: 2018-06-05
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