Objective： To analyze the composing prescriptions rules of prescriptions of Chinese medicine for coronary disease by data mining technology.Methods：Collected and arranged prescriptions of coronary disease in CNKI and literature of Chinese medicine，and established database of prescriptions.Association rules and Latent Dirichlet Allocation LDA topic model were used to respectively explore the prescriptions of coronary disease from the aspects of medicine association and latent semantic analysis of prescriptions，and to analyze the composing prescriptions rules of prescriptions of coronary disease.Results：356 cases of prescriptions of coronary disease were collected，including 318 kinds of Chinese medicine.The statistical results of medicine frequency showed that the medicines in the prescriptions mainly are qi-invigorating medicine，blood-activating and stasis-resolving medicine and qi-regulating medicine.Three topics of prescriptions were concluded by LDA topic model and 12 combinations of couplet medicines with higher upgrade degree and association rules of medicine were explored by association rules.Conclusion：Chinese medicine therapy for coronary disease focuses on tonifying qi and activating blood and resolving stasis，takes regulating qi and dispelling phlegm into consideration，and emphasizes that the treatment of the disease should attach importance to both the root cause and the symptoms.Through the analysis of the composition of prescriptions of coronary by the data method， the composing prescriptions rules can be found， which provides a reference for clinical treatment of coronary disease.