Objective：To analyze the effect of Xuesaitong injection and Nogo extracellular peptide residue 1-40(NEP1-40)on cerebral cortex and expression of serum pro-inflammatory factors and anti-inflammatory factors in SD rats with cerebral infarction.Methods：Selected 25 healthy male SD rats，and divided them into the model group，NEP1-40 group，Xuesaitong group，the sham operation group and NEP1-40 combined with Xuesaitong group(P+N group)according to the random number table method，5 SD rats in each group.Established a model of cerebral infarction according to the therapy of modified suture and embolization of Longa.Each group was given corresponding drugs.Killed the rats on the 28thday after intervention.Observed the changes of body mass and scores of neurological function of rats，and observed the level and expression of interleukin-1β(IL-1β)，tumor necrosis factor-α(TNF-α)，transforming growth factor-β1(TGF-β1)and interleukin-10(IL-10)in serum and brain tissues.Results：When compared with those in the sham operation group，the body mass of rats on the 7th，14th，and 28thday after operation in the model group was obviously decreased，scores of neurological function were obviously increased，the content of serum TNF-α and TGF-β1 was increased，while the content of IL-10 was decreased；the protein expression of TNF-α，IL-1β and TGF-β1 in brain tissues was increased，while the protein expression of IL-10 was decreased，differences were significant(P ＜ 0.05).When compared with that in the model group，the body mass on the 7th，14th，and 28thday after operation in the rats of NEP1-40 group，Xuesaitong group and P+N group was obviously increased，scores of neurological function were obviously decreased，the content of serum TNF-α was decreased，while the content of IL-10 was increased(P＜ 0.05).When compared with that in the model group，the content of serum IL-β1 in rats of P+N group was decreased；the protein expression of TNF-α and IL-1β in brain tissues of rats in Xuesaitong group and P+N group was decreased，while the protein expression of TGF-β1 and IL-10 was increased；the protein expression of TNF-α and IL-1β in brain tissues of rats in NEP1-40 group was decreased，while the protein expression of IL-10 was increased；differences were significant(P ＜ 0.05).Conclusion：Xuesaitong injection and NEP1-40 can accelerate the recovery of neurological function in ratswith cerebral infarction by adjusting the expression of pro-inflammatory and anti-inflammatory factors.