Objective：To explore the clinical effect of Duhuo Jisheng tang for knee osteoarthritis.Methods：Searched foreign language databases as PubMed and Embase and Chinese databases as CNKI，Wanfang，VIP，CBM and so on.Randomized controlled trials(RCT)literature of Duhuo Jisheng tang for knee osteoarthritis was brought into the analysis.The quality score was carried out by Cochrane system evaluation manual and the meta-analysis was conducted to analyze the total effective rate and safety.Results：Nine pieces of RCT literature were included in the control study.Meta-analysis showed the total curative effect of Duhuo Jisheng tang for knee osteoarthritis is superior to that of anti-inflammatoryanalgesics[RR=1.35，95%CI(1.12，1.63)，P=0.002＜0.05]and the differences in side effects were significant[RR=0.24，95%CI(0.13，0.47)，P＜0.01].Conclusion：Duhuo Jisheng tang has better clinical effect than anti-inflammatory analgesics in treating knee osteoarthritis，which has less adverse reactions，being suitable for clinical popularization.However，due to the low quality of the literature，it is necessary to carry out further randomized controlled studies of high quality.