中药通过调节中性粒细胞活性治疗自身免疫性疾病石开究进展
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R593.2

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澳门特区科学技术发展基金项目(FDCT: 071/2014/A)


Research Progress of Chinese Medicine for Autoimmune Disease by Adjusting Activity of Neutrophils
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    摘要:

    自身免疫性疾病(Autoimmune disease,AID)是一类异质性很强的疾病,是在多种环境因素刺激下,对机体自身的抗原产生病理性免疫反应的过程。目前还没有确切的理论解释其发病机制。中性粒细胞是非特异性免疫系统的重要一员,具有介导吞噬和杀菌的作用。近年来,作为中性粒细胞的一种全新机制,中性粒细胞胞外诱捕网(Neutrophil extracellular traps,NETs)在自身免疫性疾病上的研究备受关注。目前临床上常应用的化学药免疫抑制剂因毒副作用大而无法从根本上控制疾病的发生发展。而中药免疫抑制剂则具有毒副作用小、疗效好等特点,逐渐广泛应用于临床。笔者结合近年来的文献对NETs的形成、NETs参与AID的发生发展以及有关中药免疫抑制作用的基础研究和临床作用分别进行了综述,为进一步研究提供参考。

    Abstract:

    Autoimmune disease(AID)is a kind of disease with high heterogenicity,which is a progress that pathological immune responses was induced by antigen of oneself under the stimulation of various environmental factors.There is no definite theory to explain its pathogenesis at present.Neutrophils play an important role in non-specific immune system with functions of mediation, phagocytosis and sterilization.In recent years, neutrophil extracellular traps(NETs), a novel mechanism for neutrophils,have attracted much attention in the study of autoimmune diseases.The commonly used immunosuppressant of chemical medicine in clinic can not radically control the occurrence and development of disease for its serious side effects,while the immunosuppressant of Chinese medicine is characterized by little side effects and good efficacy and is gradually applied widely in clinic.Based on the literature in recent years,the authors carried on the review respectively on the formation of NETs,the occurrence and development of NETs participating in autoimmune disease,basic researches on immunosuppressive effect of Chinese medicine and its clinical effect,to provide a reference for further study.

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唐珊珊,徐友华.中药通过调节中性粒细胞活性治疗自身免疫性疾病石开究进展[J].新中医,2018,50(5):184-189

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  • 在线发布日期: 2018-05-03
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