Objective： To observe the clinical effect of acupoint-selecting method based on the concept of wholism combined with swallowing therapeutic instrument for post-stroke swallowing dysfunction.Methods：Divided 60 cases of patients with post-stroke swallowing dysfunction into the observation group and the control group randomly，30 cases in each case.The control group was given swallowing therapeutic instrument for treatment，while the observation group was additionally given acupoint-selecting method based on the concept of wholism for treatment.Recorded the scores of water swallow test and Fujishima's swallowing function grades of patients before and after treatment，and evaluated the clinical effect.Results：The total effective rate was 93.33%in the observation group and 83.33%in the control group，difference being insignificant(P＜0.05).The cured and remarkably effective rate was 70.00%in the observation group and 23.33%in the control group，difference being significant(P＜0.01).Before treatment，there was no significant difference being found in the scores of water swallow test and Fujishima's swallowing function grades of both groups(P＜0.05).After treatment，the scores of water swallow test in both groups were lower than those before treatment(P＜0.05)，and Fujishima's swallowing function grades in both groups were higher than those before treatment(P＜0.05)；the scores of water swallow test in the observation group were lower than those in the control group(P＜0.05)，and Fujishima's swallowing function grades in the observation group were higher than those before in the control group(P＜0.05).Conclusion：Acupoint-selecting method based on the concept of wholism combined with swallowing therapeutic instrument can effectively improve the swallowing function of patients with post-stroke swallowing dysfunction.