Objective：To observe the clinical effect of therapy of Chinese medicine comprehensive treatment combined with chemical medicine in the intervention for patients with colorectal cancer with qi deficiency and blood stasis syndrome after operation.Methods：Divided 78 cases of patients with colorectal cancer with qi deficiency and blood stasis syndrome after operation into the observation group and the control group randomly，39 cases in each group.The control group received the chemotherapy regimen of CapeOX and routine nursing measures on the 4thweek after operation，while the observation group additionally received the Chinese medicine comprehensive treatment based on the treatment of the control group，including oral administration of Yiqi Huayu tang，moxibustion on ginger and Chinese medicine nursing on emotions.Both groups continuously received treatment for three months.Compared scores of Karnofsky's performance scoring(KPS)，qi deficiency and blood stasis syndrome and EORTC quality of life questionnaires(EORTC QLQ-C30，version 3.0).Results：After treatment，scores of KPS in the control group were decreased when compared with those before treatment(P＜0.05)，while scores of KPS in the observation group were increased when compared with those before treatment(P＜0.05).After control and three months of treatment，scores of KPS in the observation group were higher than those in the control group(P＜0.05).Scores of symptoms of qi deficiency as shortness of breath，hypodynamia，spiritlessness and weak pulses in the control group were increased when compared with those before treatment(P＜0.05).Scores of symptoms of qi deficiency and blood stasis as subcutaneous ecchymosis，stabbing pain，fixed pain，blood stasis in collateral channels in the observation groupwere decreased when compared with those before treatment(P＜0.05).Every scores of symptoms in the observation group were lower than those in the control group(P＜0.05).Scores of nausea and vomiting，fatigue and pain in the control group were increased when compared with those before treatment(P＜0.05)，while scores of the four functional fields as role，body，emotion and social function were decreased when compared with those before treatment(P＜0.05).Functional scores of nausea and vomiting，role，body and emotion in the observation group were increased when compared with those before treatment(P＜0.05)，while scores of pain and social function were decreased when compared with those before treatment(P＜0.05).Scores of nausea and vomiting，fatigue and pain in the observation group were lower than those in the control group(P＜0.05)，while functional scores of role，body and emotion were higher than those in the control group(P＜0.05).No significant difference was found in the comparisons of social function and cognitive function between the two groups(P＜0.05).Conclusion：The therapy of Chinese medicine comprehensive treatment combined with chemical medicine can improve the clinical symptoms and quality of life of the patients with colorectal cancer with qi deficiency and blood stasis syndrome after operation，and promote the rehabilitation of the patients.