Objective：To observe the clinical effect of Shenkang granules for chronic uric acid nephropathy.Methods：Divided 80 cases of patients with chronic uric acid nephropathy into two groups randomly，40 cases in each group.Both groups received routine western medicine for treatment.The observation group additionally received Shenkang granules for treatment，while the control group additionally received placebos for three months.Detected scores of Chinese medicine symptoms and levels of serum creatinine(SCr)， blood urea nitrogen(BUN)，uric acid(UA)，blood β2-microglobulin and urine β2-microglobulin(β2-MG)of patients before and after treatment in both groups.Evaluated the curative effect on Chinese medicine syndrome of patients.Results：After treatment，from the aspect of curative effect on Chinese medicine syndrome，the total effective rate was 90.0% in the observation group and was 82.5% in the control group，the difference being significant(P＜0.05).Scores of Chinese medicine symptoms and levels of SCr，BUN，UA，blood β2-MG and urine β2-MG were obviously decreased when compared with those before treatment.Scores of Chinese medicine symptoms and levels of SCr，BUN，UA，blood β2-MG and urine β2-MG were remarkably lower than those in the control group，differences being significant(P＜0.05).There were two cases of stool abnormity and one case of abdominal distention and diarrhea in the observation group.There was one case of stool abnormity and two cases of abdominal distention and diarrhea in the control group.No significant difference was found in the comparison of the incidence of adverse events between the two groups(P＜0.05).Conclusion：Shenkang granules have a significant effect on treating chronic uric acid nephropathy，which can lower uric acid，improve renal function and delay the disease progression.