Objective：To observe the effect of Zishen Jiangtang pills on glucose metabolism and serum sclerostin(SOST)of patients with type 2 diabetes mellitus with yin deficiency of kidney syndrome.Methods：Divided 60 cases of patients with type 2 diabetes mellitus with yin deficiency of kidney syndrome into two groups randomly，30 cases in each group.Observed the basic condition，syndrome scores of yin deficiency of kidney syndrome，glucose metabolism indexes of blood glucose and so on， and level of serum sclerostin of patients in the two groups.Results： After treatment， Chinese medicinesyndrome scores in the treatment group were lower than those in the control group，and the respective comparisons of the effect of fasting blood glucose(FBG)，fasting insulin(FINS)，glycosylated hemoglobin(HbA1c)，SOST and increase fasting C peptide(FCP)between the two groups showed significance in differences(P＜0.05).Conclusion：Zishen Jiangtang pills can effectively decrease syndrome scores of yin deficiency of kidney syndrome，improve clinical symptoms and glucose metabolism，and obviously decrease level of serum SOST.