Objective：To observe the effect of tonify-qi therapy on Chinese medicine syndrome， motor function and activity of daily living in patients with post-stroke fatigue with qi deficiency syndrome.Methods：Selected 60 cases of patients with post-stroke fatigue with qi deficiency syndrome，and divided them into the treatment group and the control group randomly，30 cases in each group.Both groups received routine medical treatment and rehabilitation training；the control group additionally received citicoline sodium tablets for treatment，while the treatment group additionally received the prescription of Yiqi Xiaopi tang in tonify-qi therapy for treatment.The treatment of the two groups lasted for four weeks.Observed changes of Chinese medicine syndrome scores，scores of simplified Fugl-Meyer assessment scale(FMA)and modified barthel index(MBI)before and after treatment in the two groups.Results：After treatment，the total effective rate was 93.33%in the treatment group and was 76.67%in the control group，the difference being significant(P＜0.05).Scores of simplified FMA and MBI in the two groups were increased when compared with those before treatment，differences being significant(P＜0.01，P＜0.05).The above two scores in the treatment group were higher than those in the control group，differences being significant(P＜0.05).Conclusion：Based on the medical treatment and rehabilitation training，the additional administration of the prescription of Yiqi Xiaopi tang in tonify-qi therapy for patients with post-stroke fatigue can effectively relieve symptoms，eliminate fatigue，help recover energy and improve motor function，activity of daily living and quality of life，which is beneficial for patients to early returning to family and society.