Objective：Under the intervention of Shenling Baizhu powder，the representative prescription in the method of strengthening earth to generate metal，to observe the content changes of Ghrelin，Obestatin，leptin and inflammatory factors interleukin(IL)-1，tumor necrosis factor(TNF)-α in serum of model rats with chronic obstructive pulmonary diseases(COPD)of lung and spleen deficiency type，explore the mechanism of the method of strengthening earth to generate metal in treating COPD，and to provide theoretical basis for the method in clinical prevention and treatment for COPD.Methods： Divided 60 Wistar rats randomly into the blank group，the model group and the medicine intervention group based on the medicine intervention time subdivided into the 28 d，35 d and 42 d groups，12 rats in each group.Except the blank group，the rats in the model group and the medicine intervention group were given fumigation，endotracheal injection of lipopolysaccharide and infusion of cold folium sennae immersion liquid to establish models of rats with COPD of lung and spleen deficiency type.The medicine intervention group was additionally given Shenling Baizhu powder by gavage for treatment.On the 28 d，35 d and 42 d of medicine intervention，determined the lung function of rats in each group and sacrificed after draw blood.Detected content changes of Ghrelin，Obestatin，leptin，IL-1 and TNF-α in serum of rats in each group with Elisa method.Results：Compared with those in the blank group，the respiratory frequency(F value)in the model group was increased，while the indexes of lung volume(TV)，the flow indexes(EF50)and the pulmonary dynamic compliance(Cdyn)were significantly reduced(P＜0.05)；contents of Ghrelin and Obestatin in serum were obviously decreased(P＜0.05)；contents of IL-1，TNF-α and leptin were remarkably increased(P＜0.05).Compared with those in the model group，F value of rats in every subgroups of the medicine intervention group was decreased，while values of TV，EF50 and Cdyn were significantly increased(P＜0.05)；contents of Ghrelin and Obestatin in serum were increased in different degrees(P＜0.05)；contents of IL-1，TNF-α and leptin in serum were obviously decreased(P＜0.05).Compared with the 28 d group of Shenling Baizhu powder，the F value and TNF-α in the 42 d group of Shenling Baizhu powder were decreased，while contents of Cdyn and Obestatin content were increased(P＜0.05).Conclusion：The method of strengthening earth to generate metal can improve the malnutrition condition of rats with COPD of lung and spleen deficiency type，improve the lung function and postpone the development process of COPD.The mechanism is probably to up-regulate the expression of Ghrelin and Obestatin in serum and to down-regulate the expression of leptin and inflammatory factors in serum.The intergroup difference in the medicine intervention group shows that the early application of the method of strengthening earth to generate metal has protective effect on rats with COPD，indicating the prevention and treatment for COPD of the method.