Objective： To observe the clinical effect of modified Shugan Tongluo tang combined with Xingnao Kaiqiao acupuncture for post-stroke depression(PSD)and itseffect on score of Hamilton depression rating scale(HAMD)，brain-derived neurotrophic factor(BDNF)，and level of 5-hydroxytryptamine(5-HT).Methods：Selected 120 cases of patients with PSD and then divided them into the control group and the study group randomly，60 cases in each group.Both groups were givenroutine therapy，while the control group was additionally given amitriptyline tablets and the study group was additionally given modified Shugan Tongluo tang combined with Xingnao Kaiqiao acupuncture for treatment.The treatment lasted for two months in both groups.Observed scores of HAMD，changes of level of BDNF in serum，and 5-HT before and after treatment.Results：Before treatment，there was no significant difference being found in the comparison of scores of HAMD in both groups(P ＞ 0.05).After treatment，the scores of HAMD in both groups were decreased when compared with those before treatment，differences being significant(P ＜ 0.05).Scores of HAMD in the study group were lower than those in the control group，difference being significant(P＜0.05).The clinical effect in the study group was better than that in the control group，difference being significant(Z=2.701，P ＜ 0.05).Before treatment，there was no significant difference being found in the comparisons of levels of BDNF in serum and 5-HT in both groups，differences being insignificant(P＞0.05).After treatment，levels of BDNF in serum and 5-HT in both groups were higher than those before treatment，differences being significant(P＜ 0.05).Levels of BDNF in serum and 5-HT in the study group were higher than those in the control group，differences being significant(P＜0.05).Conclusion：The application of modified Shugan Tongluo tang combined with Xingnao Kaiqiao acupuncture has a significant clinical effect in treating PSD and can effectively relieve depression of patients and increase BDNF in serum and level of 5-HT.