Objective：To observe the clinical effect of Xiaoyou tang combined with photodynamic therapy for refractory plantar wart.Methods：Selected 60 cases of patients with refractory plantar wart with dampness-heat and blood stasis syndrome and divided them randomly into two groups，30 cases in each group.The control group was given aminolevulinic acid hydrochloride and photodynamic therapy combined with tretinoin ointment，while the treatment group was additionally given fumigation and washing with Xiaoyou tang based on the treatment of the control group.Observed changes of the number of plantar wart，diameter of skin lesions and pain score in two groups before and after treatment，and observed the clinical effect after treatment and recurrence after one year.Results：After treatment of two to three months，the total effective rate in the treatment group was higher than that in the control group(P＜0.05).The number of plantar wart in two groups was reduced when compared with that before treatment(P＜0.05).The diameter of skin lesions in two groups was smaller than that before treatment(P＜0.05).The pain scores in two groups were decreased when compared with those before treatment(P＜ 0.05).The number of plantar wart in the treatment group was less than that in the control group，diameter of skin lesions was less than that in the control group，and pain scores were less than that in the control group as well，differences being significant(P ＜ 0.05).After treatment of one year，the recurrence rate was 13.33%in the treatment group and was 40.00%in the control group，the difference being significant(P ＜ 0.05).Conclusion：The therapy of Xiaoyou tang combined with photodynamic therapy has good effect in treating refractory plantar wart，which can greatly relieve the malaise of patients and decrease the recurrence rate.The therapy is worthy of clinical application.