凉血逐瘀汤联合孟鲁司特钠咀嚼片治疗小儿过敏性紫癜血热妄行证临床观察
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R554+.6

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河南省中医药科学研究专项课题(2015ZY02008)


Clinical Observation of Liangxue Zhuyu Tang Combined with Montelukast Sodium Chewable Tablets for Henoch-Schordein Purpura with Bleeding Due to Blood-heat Syndrome in Children
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    摘要:

    目的:观察凉血逐瘀汤联合孟鲁司特钠咀嚼片治疗小儿过敏性紫癜(HSP)血热妄行证的临床疗效。方法:选取137例HSP血热妄行证患儿作为研究对象,采用随机数字表法分为观察组68例与对照组69例。对照组予孟鲁司特钠咀嚼片治疗,观察组在对照组治疗基础上加用凉血逐瘀汤。2组均连续治疗2周后评估临床疗效,记录临床症状体征的消退或缓解时间,观察治疗前后相关炎症因子、T细胞亚群指标的变化。结果:观察组总有效率92.65%,对照组总有效率76.81%,2组比较,差异有统计学意义(P<0.05)。观察组皮肤紫癜、关节肿痛、腹痛、血尿及蛋白尿缓解或消失时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,2组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6) 与白细胞介素-8(IL-8) 水平均较治疗前下降(P<0.05);观察组3项炎症因子水平均低于对照组(P<0.05)。与治疗前比较,治疗后2组CD4+、CD4+/CD8+值均上升,CD8+值均下降(P<0.05)。治疗后观察组CD4+与CD4+/CD8+值均高于对照组(P<0.05),CD8+值低于对照组(P<0.05)。结论:凉血逐瘀汤联合孟鲁司特钠咀嚼片治疗HSP血热妄行证疗效显著,可有效缓解患儿的症状体征,缩短病程,提高细胞免疫功能,抗炎作用明显。

    Abstract:

    Objective:To observe the clinical effect of Liangxue Zhuyu tang combined with montelukast sodium chewable tablets for henoch-schordein purpura(HSP)with frenetic blood movement due to blood-heat syndrome in children.Methods:Selected 137 cases of children with HSP with frenetic blood movement due to heat syndrome as study objects and divided them into two groups according to the random number table method,68 cases in the observation group and 69 cases in the control group.The control group received montelukast sodium chewable tablets for treatment,while the observation group additionally received Liangxue Zhuyu tang based on the treatment of the control group.After the two groups continuously received treatment for 2 weeks,evaluated the clinical effect,recorded the regression or remission time of clinical symptoms and body signs,and observed changes of related indexes of inflammatory factors and T cell subsets before and after treatment.Results:The total effective rate was 92.65%in the observation group and was 76.81%in the control group,the difference being significant(P < 0.05).The remission or regression time of skin purpura, swelling and aching in joint,abdominal pain,hematuria and proteinuria in the observation group was shorter than that in the control group,differences being significant(P < 0.05).After treatment, levelsof tumor necrosisfactor-α (TNF-α), interleukins-6(IL-6)and interleukins-8(IL-8)in the two groups were decreased when compared with those before treatment(P<0.05).Levels of the three inflammatory factors in the observation group were all lower than those in the control group(P<0.05).When compared before treatment,values of CD4+and CD4+/CD8+in the two groups after treatment were increased,while the CD8+value was decreased(P < 0.05).After treatment,values of CD4+and CD4+/CD8+in the observation group were higher than those in the control group(P < 0.05),while the CD8+value was lower(P < 0.05).Conclusion:The therapy of Liangxue Zhuyu tang combined with montelukast sodium chewable tablets has significant effect in treating HSP with bleeding due to blood-heat in children,which can effectively relieve symptoms and body signs of children,shorten the course of disease and improve the immune function of cells with obvious anti-inflammatory effect.

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秦瑞君,王宏杰,孟牛安.凉血逐瘀汤联合孟鲁司特钠咀嚼片治疗小儿过敏性紫癜血热妄行证临床观察[J].新中医,2018,50(4):136-139

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  • 在线发布日期: 2018-04-10
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