Objective：To observe the clinical effect of Liangxue Zhuyu tang combined with montelukast sodium chewable tablets for henoch-schordein purpura(HSP)with frenetic blood movement due to blood-heat syndrome in children.Methods：Selected 137 cases of children with HSP with frenetic blood movement due to heat syndrome as study objects and divided them into two groups according to the random number table method，68 cases in the observation group and 69 cases in the control group.The control group received montelukast sodium chewable tablets for treatment，while the observation group additionally received Liangxue Zhuyu tang based on the treatment of the control group.After the two groups continuously received treatment for 2 weeks，evaluated the clinical effect，recorded the regression or remission time of clinical symptoms and body signs，and observed changes of related indexes of inflammatory factors and T cell subsets before and after treatment.Results：The total effective rate was 92.65%in the observation group and was 76.81%in the control group，the difference being significant(P ＜ 0.05).The remission or regression time of skin purpura， swelling and aching in joint，abdominal pain，hematuria and proteinuria in the observation group was shorter than that in the control group，differences being significant(P ＜ 0.05).After treatment， levelsof tumor necrosisfactor-α (TNF-α)， interleukins-6(IL-6)and interleukins-8(IL-8)in the two groups were decreased when compared with those before treatment(P＜0.05).Levels of the three inflammatory factors in the observation group were all lower than those in the control group(P＜0.05).When compared before treatment，values of CD4+and CD4+/CD8+in the two groups after treatment were increased，while the CD8+value was decreased(P ＜ 0.05).After treatment，values of CD4+and CD4+/CD8+in the observation group were higher than those in the control group(P ＜ 0.05)，while the CD8+value was lower(P ＜ 0.05).Conclusion：The therapy of Liangxue Zhuyu tang combined with montelukast sodium chewable tablets has significant effect in treating HSP with bleeding due to blood-heat in children，which can effectively relieve symptoms and body signs of children，shorten the course of disease and improve the immune function of cells with obvious anti-inflammatory effect.