Objective： To observe the clinical effect of modified Liuwei Dihuang tang combined with tinidazole vaginal effervescent tablets for senile vaginitis.Methods：Selected 66 cases of patients with senile vaginitis， and divided them into the control group and the research group randomly，33 cases in each group.The control group received tinidazole vaginal effervescent tablets for treatment，while the research group additionally received modified Liuwei Dihuang tang for treatment.Recorded vagina health scores and vaginal inflammation symptom scores of patients before and after treatment，and evaluated the clinical effect.Results：After treatment，vagina health scores in the two groups were all gradually decreased，differences being significant(P ＜ 0.05).In the 1stcourse of treatment，compared vagina health scores in both groups，there was no significant difference being found(P ＞ 0.05).In the 2ndand 3rdcourse of treatment，vagina health scores in the research group were all lower than those in the control group，difference being significant(P ＜ 0.05).After treatment，vaginal inflammation symptom scores in the two groups were all gradually decreased，differences being significant(P ＜ 0.05)；vaginal inflammation symptom scores in the research group were all lower than those in the control group in the same period，differences being significant(P＜0.05).The cure rate was 60.61%and the total effective rate was 96.97%in the research group，while the cure rate was 30.30%and the total effective rate was 84.85%in the control group.Compared the cure rate in both groups，there was significant difference being found(P ＜ 0.05).Compared the total effective rate in both groups，there was no significant difference being found(P＞0.05).Conclusion：Modified Liuwei Dihuang tang combined with tinidazole vaginal effervescent tablets in treating senile vaginitis can effectively improve symptoms and signs of patients and increase the cure rate.