Objective：To observe the clinical effect of Huoxue Zhuyu tang for adenomyosis and its effect on inflammatory factors.Methods：Selected 121 cases of patients with adenomyosis of qi stagnation and blood stasis type and divided them into the observation group and the control group randomly，respectively 62 cases and 59 cases in each group.The control group received oral administration of ibuprofen sustained release capsules for treatment when pain began and stopped taking when pain disappeared.The observation group received Chinese medicine of Huoxue Zhuyu tang for ten days as a course every menstrual cycle.Both groups continuously received treatment for three menstrual cycles.Observed the clinical effect in both groups.Recorded and compared scores of pain degree and symptoms in both groups before and after treatment.Detected and compared levels of serum inflammatory factors in both groups.Observed whether there were adverse reactions in both groups.Results：The total effective rate was 72.58%in the observation group，higher than that in the control group，which was 42.37%，the difference being significant(P＜0.05).After treatment，Chinese medicine syndrome scores and VAS scores in both groups were decreased when compared with those before treatment，while Chinese medicine syndrome scores and VAS scores in the observation group were lower than those in the control group，differences being significant(P＜0.05).After treatment，Levels of IL-6，PGE2and PGF2αin both groups were decreased when compared with those before treatment， while levels of IL-6， PGE2and PGF2αin the observation group were lower than those in the control group，differences being significant(P＜0.05).Conclusion：Huoxue Zhuyu tang can remarkably improve clinical symptoms and pain degree，decrease levels of inflammatory factors and effectively in treating adenomyosis.