Objectives： To observe the clinical effect of integrated Chinese and western medicine therapy for threatened abortion of kidney deficiency type during early pregnancy.Methods：Selected 110 cases of patients with threatened abortion of kidney deficiency type during early pregnancy as study subjects，and divided them randomly into the the control group and the study group，55 cases in each group.The control group received routine western medicine for treatment，while the study group was additionally given oral Chinese medicine decoction based on the treatment of the control group.After treatment，observed the improvement of clinical symptoms in the two groups and changes of vascular endothelial growth factor(VEGF)，serum progesterone(P)，human chorionic gonadotropin(β-HCG)，estradiol(E2)，CD4+cells，CD8+cells，natural killer(NK)cells and total T cells.Results：In the control group，the cure rate was 41.82%and the total effective rate was 78.18%.In the study group，the cure rate was 61.82%and the total effective rate was 96.36%.The comparisons of the cure rate and the total effective rate between the two groups showed significance in differences(P ＜ 0.05).After treatment，scores of vaginal bleeding，bearing-down pain of lower abdomen，soreness and distending pain of loins，soreness and weakness of knees，dizziness and tinnitus as well as frequent and much urination at night in the two groups were decreased when compared with those before treatment(P＜0.05).These six scores of clinical symptoms in the study group were lower than those in the control group(P ＜ 0.05).After treatment， levels of VEGF， P， β-HCG and E2in the two groups were increased when compared with those before treatment(P＜0.05).Levels of these four indexes in the study group were higher than those in the control group(P ＜ 0.05).After treatment，levels of CD4+were decreased in the two groups when compared with those before treatment(P ＜ 0.05)，CD8+，NK cells and total T cells in the two groups were increased when compared with those before treatment(P ＜ 0.05).Levels of CD8+，NK cells and total T cells in the study group were higher than those in the control group(P＜0.05).Conclusion：Integrated Chinese and western medicine therapy has a significant effect in treating threatened abortion of kidney deficiency type during early pregnancy，which can effectively improve the clinical symptoms of patients and improve the immunologic function.